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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-3-31
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pubmed:abstractText |
The only approved pharmacological approach for the symptomatic treatment of Alzheimer's disease in Japan is the use of a cholinesterase inhibitor, donepezil hydrochloride. Recent in vivo and in vitro studies raise the possibility that cholinesterase inhibitors can slow the progression of Alzheimer's disease. The purpose of the present study was to determine whether donepezil has a neuroprotective effect in Alzheimer's disease by using the rate of hippocampal atrophy as a surrogate marker of disease progression.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0002-953X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
162
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
676-82
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15800138-Aged,
pubmed-meshheading:15800138-Alzheimer Disease,
pubmed-meshheading:15800138-Apolipoproteins E,
pubmed-meshheading:15800138-Atrophy,
pubmed-meshheading:15800138-Cholinesterase Inhibitors,
pubmed-meshheading:15800138-Cohort Studies,
pubmed-meshheading:15800138-Disease Progression,
pubmed-meshheading:15800138-Dose-Response Relationship, Drug,
pubmed-meshheading:15800138-Drug Administration Schedule,
pubmed-meshheading:15800138-Female,
pubmed-meshheading:15800138-Genotype,
pubmed-meshheading:15800138-Geriatric Assessment,
pubmed-meshheading:15800138-Hippocampus,
pubmed-meshheading:15800138-Humans,
pubmed-meshheading:15800138-Indans,
pubmed-meshheading:15800138-Longitudinal Studies,
pubmed-meshheading:15800138-Magnetic Resonance Imaging,
pubmed-meshheading:15800138-Male,
pubmed-meshheading:15800138-Neuroprotective Agents,
pubmed-meshheading:15800138-Piperidines,
pubmed-meshheading:15800138-Prospective Studies,
pubmed-meshheading:15800138-Psychiatric Status Rating Scales,
pubmed-meshheading:15800138-Time Factors,
pubmed-meshheading:15800138-Treatment Outcome
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pubmed:year |
2005
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pubmed:articleTitle |
Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?
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pubmed:affiliation |
Hyogo Institute for Aging Brain and Cognitive Disorders, Hyogo, Japan. qq257xk9@minos.ocn.ne.jp
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Controlled Clinical Trial
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