15799547

Source:http://linkedlifedata.com/resource/pubmed/id/15799547

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002736, umls-concept:C0008976, umls-concept:C1705294, umls-concept:C1707689
pubmed:issue	4
pubmed:dateCreated	2005-3-31
pubmed:abstractText	The objective of this paper is to discuss the sequential trial design and its advantages in clinical trials for ALS. The sequential trial design is an alternative to the classical trial design, which permits stopping a study as soon as a treatment effect can be significantly demonstrated or denied.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/100964775
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Creatine
pubmed:status	MEDLINE
pubmed:month	Dec
pubmed:issn	1466-0822
pubmed:author	pubmed-author:GroeneveldGeert JanGJ, pubmed-author:WokkeJohn H JJH, pubmed-author:van den BergLeonard HLH, pubmed-author:van der TweelIngeborgI
pubmed:issnType	Print
pubmed:volume	5
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	202-7
pubmed:dateRevised	2007-11-15
pubmed:meshHeading	pubmed-meshheading:15799547-Amyotrophic Lateral Sclerosis, pubmed-meshheading:15799547-Confidence Intervals, pubmed-meshheading:15799547-Creatine, pubmed-meshheading:15799547-Double-Blind Method, pubmed-meshheading:15799547-Humans, pubmed-meshheading:15799547-Randomized Controlled Trials as Topic, pubmed-meshheading:15799547-Research Design, pubmed-meshheading:15799547-Sample Size, pubmed-meshheading:15799547-Survival Analysis
pubmed:year	2004
pubmed:articleTitle	Sequential designs for clinical trials in amyotrophic lateral sclerosis.
pubmed:affiliation	Department of Neurology, University Medical Centre, Heidelberglaan 100, NL-3584 CX Utrecht, The Netherlands. g.j.groeneveld@neuro.azu.nl
pubmed:publicationType	Journal Article, Comparative Study