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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1992-6-8
|
| pubmed:abstractText |
A proportion of the antibodies produced by mice in response to the injection of rat erythrocytes (RRBC) cross-react with autologous red cells. When spleen cells from mice so immunized are transferred to naive syngeneic recipients, the recipient mice produce high anti-RRBC antibody titres but little or no autoantibody. This phenomenon has been attributed to the action of suppressor T cells. To date, the only mouse strain which consistently fails to demonstrate specific suppression of the autoantibody response is the SJL, which lacks the I-E molecules suggested to be important in the generation of suppressor T cells. The results presented here show that some, but not all, I-E negative strains of mice are capable of exhibiting transferable suppression of RRBC-induced antibodies.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0300-9475
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
511-6
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1579856-Animals,
pubmed-meshheading:1579856-Antibody Specificity,
pubmed-meshheading:1579856-Autoantibodies,
pubmed-meshheading:1579856-Coombs' Test,
pubmed-meshheading:1579856-Erythrocyte Transfusion,
pubmed-meshheading:1579856-Erythrocytes,
pubmed-meshheading:1579856-Female,
pubmed-meshheading:1579856-Histocompatibility Antigens Class II,
pubmed-meshheading:1579856-Immunity, Cellular,
pubmed-meshheading:1579856-Immunization, Passive,
pubmed-meshheading:1579856-Immunosuppression,
pubmed-meshheading:1579856-Male,
pubmed-meshheading:1579856-Mice,
pubmed-meshheading:1579856-Mice, Inbred C57BL,
pubmed-meshheading:1579856-Mice, Inbred NOD,
pubmed-meshheading:1579856-Mice, Inbred Strains,
pubmed-meshheading:1579856-Rats,
pubmed-meshheading:1579856-Spleen
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
The influence of I-E on the generation of autoantibody and specific suppression in rat erythrocyte-immunized mice.
|
| pubmed:affiliation |
Department of Molecular Immunology, National Institute for Medical Research, Mill Hill, London, UK.
|
| pubmed:publicationType |
Journal Article
|