| pubmed-article:15797961 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0031671 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0086376 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C1531127 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C1622340 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C2611812 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0205227 | lld:lifeskim |
| pubmed-article:15797961 | lifeskim:mentions | umls-concept:C0597765 | lld:lifeskim |
| pubmed-article:15797961 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:15797961 | pubmed:dateCreated | 2005-5-26 | lld:pubmed |
| pubmed-article:15797961 | pubmed:abstractText | Neuropeptides B and W (NPB and NPW) are regulatory peptides that act via two subtypes of G protein-coupled receptors, named GPR7 and GPR8. RT-PCR demonstrated the expression of these receptors in both zona glomerulosa and zona fasciculata-reticularis (ZF/R) cells of the human adrenal cortex. NPB and NPW did not affect aldosterone secretion from dispersed zona glomerulosa cells but enhanced cortisol production from ZF/R cells, NPB being more effective than NPW. NPB evoked sizable cAMP and inositol triphosphate responses from ZF/R cells, which were abrogated by the adenylate cyclase inhibitor SQ-22536 and the phospholipase C inhibitor U-73122, respectively. Cortisol response to NPB was lowered by either SQ-22536 and the protein kinase (PK) A inhibitor H-89 or U-73122 and the PKC inhibitor calphostin-C and abolished by the simultaneous exposure to H-89 and calphostin-C. NPW elicited only a rise in cAMP production from dispersed ZF/R cells, and its cortisol response was suppressed by both SQ-22536 and H-89. PreproNPB and preproNPW mRNAs were detected in human adrenal cortexes. We conclude that: 1) NPB and NPW exert a secretagogue action on human ZF/R cells, probably acting in an autocrine-paracrine manner; and 2) the effect of NPB is mediated by both the adenylate cyclase/PKA and the phospholipase C/PKC cascades, whereas that of NPW involves only the activation of the former signaling pathway. | lld:pubmed |
| pubmed-article:15797961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15797961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15797961 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:15797961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15797961 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:15797961 | pubmed:issn | 0021-972X | lld:pubmed |
| pubmed-article:15797961 | pubmed:author | pubmed-author:MazzocchiGG | lld:pubmed |
| pubmed-article:15797961 | pubmed:author | pubmed-author:NussdorferG... | lld:pubmed |
| pubmed-article:15797961 | pubmed:author | pubmed-author:MalendowiczL... | lld:pubmed |
| pubmed-article:15797961 | pubmed:author | pubmed-author:RebuffatPP | lld:pubmed |
| pubmed-article:15797961 | pubmed:author | pubmed-author:RossiG PGP | lld:pubmed |
| pubmed-article:15797961 | pubmed:author | pubmed-author:ZiolkowskaAA | lld:pubmed |
| pubmed-article:15797961 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15797961 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:15797961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15797961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15797961 | pubmed:pagination | 3466-71 | lld:pubmed |
| pubmed-article:15797961 | pubmed:dateRevised | 2008-5-7 | lld:pubmed |
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| pubmed-article:15797961 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15797961 | pubmed:articleTitle | G protein receptors 7 and 8 are expressed in human adrenocortical cells, and their endogenous ligands neuropeptides B and w enhance cortisol secretion by activating adenylate cyclase- and phospholipase C-dependent signaling cascades. | lld:pubmed |
| pubmed-article:15797961 | pubmed:affiliation | Department of Human Anatomy and Physiology, Section of Anatomy, University of Padova, Via Gabelli 65, I-35121 Padova, Italy. | lld:pubmed |
| pubmed-article:15797961 | pubmed:publicationType | Journal Article | lld:pubmed |
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