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pubmed-article:15797745pubmed:abstractTextCardiac allograft vasculopathy (CAV) limits survival after cardiac transplantation. Tumor necrosis factor-alpha (TNF-alpha) may be a key factor in the development of CAV. Two bi-allelic polymorphisms associated with high TNF-alpha production have been identified in the TNF gene locus, TNFA1/2, at position -308 and TNFB1/2 at +252. We hypothesized that recipient TNFA2 and TNFB2 homozygosity is associated with the development of CAV after heart transplantation.lld:pubmed
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pubmed-article:15797745pubmed:articleTitleTumor necrosis factor gene polymorphism and cardiac allograft vasculopathy.lld:pubmed
pubmed-article:15797745pubmed:affiliationDepartment of Cardiothoracic Surgery, Sahlgrenska University Hospital, Göteborg, Sweden.lld:pubmed
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