Linked Life Data

1579729

Source:http://linkedlifedata.com/resource/pubmed/id/1579729

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1992-6-10
pubmed:abstractText
A potential role of surfactant in COPD pathogenesis is not yet clearly demonstrated. Cigarette smoke is an important risk factor for COPD and it is known to adversely affect surfactant. In a series of 20 smoker, non-asthmatic COPD patients compared with 5 nonsmoker healthy controls we found a marked decrease (about 6-7 times) of total phospholipids in bronchoalveolar lavage fluids. We were not able to find differences in % composition, with the exception of phosphatidylglycerol-cardiolipin, which appeared significantly increased in smoker COPD patients (p less than 0.02). An alteration of mucociliary clearance and an impairment of antimicrobial defence might be important surfactant related factors in COPD, but no definitive data are available. We do not know at present if a therapy increasing surfactant would be of any value in COPD treatment. Surfactant replacement therapy is at present advisable only for those conditions in which a surfactant impairment plays (IRDS) or seems to play (ARDS) a crucial role. Pharmacologic stimulation of type 2 pneumocytes could have several advantages over replacement therapy. Ambroxol is probably one of the most promising surfactant stimulating agents, but preliminary data show that in smoker COPD patients drug dosages higher than those usually employed to affect bronchial mucus are necessary to obtain a significant increase of surfactant phospholipids.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0025-7931
pubmed:author
pubmed:issnType
Print
pubmed:volume
59 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
28-32
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Role of surfactant in chronic obstructive pulmonary disease: therapeutic implications.
pubmed:affiliation
Division of Pulmonary Disease, Medical Center of Rehabilitation, Clinica del Lavoro Foundation, Veruno (NO), Italy.
pubmed:publicationType
Journal Article, Review