Source:http://linkedlifedata.com/resource/pubmed/id/15796770
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2005-3-30
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pubmed:abstractText |
Women are twice as likely to suffer from mood disorders than men. Moreover, a growing body of evidence suggests a reciprocal modulation between sex steroids and the serotonin (5-HT) system. A previous study from our laboratory has shown that the progesterone metabolites 5beta-pregnane-3,20-dione (5beta-DHP) and 5alpha-pregnan-3alpha-ol,20-one (3alpha,5alpha-THP), as well as dehydroepiandrosterone (DHEA), increase the firing activity of dorsal raphe nucleus (DRN) 5-HT neurones in female rats. The present study was undertaken to assess the effects of these steroids in male rats, as well as the effects of testosterone and 17beta-oestradiol (17beta-E) in both sexes, and finally to evaluate gender differences in the modulation of the 5-HT neuronal firing activity by these different neuroactive steroids. Male rats were treated i.c.v., for 7 days, with a dose of 50 microg/kg/day of one of the following steroids: progesterone, 5beta-DHP, 3alpha,5alpha-THP, DHEA, testosterone, 17beta-hydroxy-5alpha-androstan-3-one (5alpha-DHT) and 17beta-E. Some rats also received a 3-day administration of testosterone (50 microg/kg/day, i.c.v). Females were treated in the same fashion with testosterone and 17beta-E. Extracellular unitary recordings of 5-HT neurones, obtained in vivo in the DRN of these rats, revealed that testosterone and 17beta-E increased the firing activity of 5-HT neurones in both males and females. In males, the effect of testosterone could already be seen after 3 days of treatment. Neither castration nor any treatment with other steroids significantly modified the firing rate of male 5-HT neurones. Taken together with previous findings, the results of the present study indicate both similarities and differences between sexes in the modulation of 5-HT neurones by some steroids. This could prove important in understanding gender differences in mood disorders.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0953-8194
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
179-85
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15796770-Action Potentials,
pubmed-meshheading:15796770-Analysis of Variance,
pubmed-meshheading:15796770-Animals,
pubmed-meshheading:15796770-Electrophysiology,
pubmed-meshheading:15796770-Estradiol,
pubmed-meshheading:15796770-Female,
pubmed-meshheading:15796770-Gonadal Steroid Hormones,
pubmed-meshheading:15796770-Injections, Intraventricular,
pubmed-meshheading:15796770-Male,
pubmed-meshheading:15796770-Neurons,
pubmed-meshheading:15796770-Patch-Clamp Techniques,
pubmed-meshheading:15796770-Raphe Nuclei,
pubmed-meshheading:15796770-Rats,
pubmed-meshheading:15796770-Rats, Sprague-Dawley,
pubmed-meshheading:15796770-Serotonin,
pubmed-meshheading:15796770-Sex Factors,
pubmed-meshheading:15796770-Testosterone
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pubmed:year |
2005
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pubmed:articleTitle |
Oestrogen and testosterone modulate the firing activity of dorsal raphe nucleus serotonergic neurones in both male and female rats.
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pubmed:affiliation |
Department of Psychiatry, McGill University, Montréal, Québec, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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