Source:http://linkedlifedata.com/resource/pubmed/id/15796166
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2005-3-30
|
| pubmed:abstractText |
We investigated the anti-metastatic effect of cordycepin (3'-deoxyadenosine) on a hematogenic metastatic mouse model which was intravenously injected with B16-BL6 melanoma cells. A 3-hour exposure to various concentrations of cordycepin (0.3, 1 and 3 microg/ml) dose-dependently reduced the number of nodules formed in lung at 15 days after the tumor injection. To elucidate the mechanism of this anti-metastatic effect, we examined the effect of cordycepin on the invasiveness of B16-BL6 cells using a chemo-invasion chamber in vitro. The B16-BL6 cells pretreated with cordycepin (3 microg/ml) for 3 hours showed a significant decrease in invasiveness. Under the same conditions, however, cordycepin did not influence the growth curve of B16-BL6 cells at concentrations up to 3 microg/ml. These results suggest that cordycepin exerts an anti-metastatic action, in part, by inhibiting the invasiveness of mouse melanoma cells.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0258-851X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
137-41
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15796166-Animals,
pubmed-meshheading:15796166-Antineoplastic Agents,
pubmed-meshheading:15796166-Deoxyadenosines,
pubmed-meshheading:15796166-Disease Models, Animal,
pubmed-meshheading:15796166-Dose-Response Relationship, Drug,
pubmed-meshheading:15796166-Female,
pubmed-meshheading:15796166-Injections, Intravenous,
pubmed-meshheading:15796166-Lung Neoplasms,
pubmed-meshheading:15796166-Melanoma, Experimental,
pubmed-meshheading:15796166-Mice,
pubmed-meshheading:15796166-Mice, Inbred C57BL,
pubmed-meshheading:15796166-Neoplasm Invasiveness,
pubmed-meshheading:15796166-Neoplasm Metastasis,
pubmed-meshheading:15796166-Neoplasm Transplantation,
pubmed-meshheading:15796166-Specific Pathogen-Free Organisms,
pubmed-meshheading:15796166-Time Factors,
pubmed-meshheading:15796166-Tumor Cells, Cultured
|
| pubmed:articleTitle |
Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice.
|
| pubmed:affiliation |
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo 663-8179, Japan. lfp51193@mwu.mukogawa-u.ac.jp
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|