|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0035143,
umls-concept:C0059438,
umls-concept:C0079904,
umls-concept:C0185117,
umls-concept:C0475264,
umls-concept:C0684249,
umls-concept:C1314939,
umls-concept:C2699153,
umls-concept:C2911684
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2005-3-29
|
|
pubmed:abstractText |
Epigallocatechin-3-gallate (EGCG) repressed the invasion of lung carcinoma 95-D cells in invasion assay. RT-PCR analysis illuminated that 40 microM EGCG down-regulated the expression of MMP-9 by 45.7% and the result of Western blot analysis provided further evidence. NF-kappa B localized in the nucleus of the 95-D cells was diminished in a dose-dependent manner in EGCG-treated cells as shown by Western blot. Intracellular oxidants were more abundant in invasive cells than in invasion-suppressed cells fed with EGCG for 18 h. Thus, the inhibition of tumor invasion by EGCG was shown to be attributed to decreases of the expression of MMP-9 and NF-kappa B, which may result from decrease of intracellular oxidants.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0753-3322
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
59
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
98-103
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15795102-Antioxidants,
pubmed-meshheading:15795102-Blotting, Western,
pubmed-meshheading:15795102-Catechin,
pubmed-meshheading:15795102-Down-Regulation,
pubmed-meshheading:15795102-Humans,
pubmed-meshheading:15795102-Lung Neoplasms,
pubmed-meshheading:15795102-Matrix Metalloproteinase 9,
pubmed-meshheading:15795102-NF-kappa B,
pubmed-meshheading:15795102-Neoplasm Metastasis,
pubmed-meshheading:15795102-Reactive Oxygen Species,
pubmed-meshheading:15795102-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:15795102-Tumor Cells, Cultured
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Repressions of MMP-9 expression and NF-kappa B localization are involved in inhibition of lung carcinoma 95-D cell invasion by (-)-epigallocatechin-3-gallate.
|
|
pubmed:affiliation |
State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, PR China.
|
|
pubmed:publicationType |
Journal Article
|
