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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2005-3-31
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AL929409,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY917123,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AY917124,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/CAB89629,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NM_018249,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NM_018451,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NM_145990,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/NP_649701,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/XM_127861,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/XP_127861,
http://linkedlifedata.com/resource/pubmed/xref/RefSeq/XP_224232
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pubmed:abstractText |
Autosomal recessive primary microcephaly is a potential model in which to research genes involved in human brain growth. We show that two forms of the disorder result from homozygous mutations in the genes CDK5RAP2 and CENPJ. We found neuroepithelial expression of the genes during prenatal neurogenesis and protein localization to the spindle poles of mitotic cells, suggesting that a centrosomal mechanism controls neuron number in the developing mammalian brain.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1061-4036
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pubmed:author |
pubmed-author:BaralleDianaD,
pubmed-author:BennettChristopherC,
pubmed-author:BondJacquelynJ,
pubmed-author:CorryPeterP,
pubmed-author:CostaSuzana M RSM,
pubmed-author:HampshireDaniel JDJ,
pubmed-author:HigginsJulieJ,
pubmed-author:JafriHussainH,
pubmed-author:KarbaniGulshanG,
pubmed-author:LealGabriella FGF,
pubmed-author:LizarragaSofia BSB,
pubmed-author:LizarragaSophiaS,
pubmed-author:MorrisonEwan EEE,
pubmed-author:RaponiMichelaM,
pubmed-author:RashidYasminY,
pubmed-author:RobertsEmmaE,
pubmed-author:ScottSheilaS,
pubmed-author:SilvaElias OEO,
pubmed-author:SpringellKellyK,
pubmed-author:WalshChristopher ACA,
pubmed-author:WoodsC GeoffreyCG
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
353-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:15793586-Animals,
pubmed-meshheading:15793586-Brain,
pubmed-meshheading:15793586-Centrosome,
pubmed-meshheading:15793586-Female,
pubmed-meshheading:15793586-Gene Expression Regulation, Developmental,
pubmed-meshheading:15793586-Genes, Recessive,
pubmed-meshheading:15793586-HeLa Cells,
pubmed-meshheading:15793586-Homozygote,
pubmed-meshheading:15793586-Humans,
pubmed-meshheading:15793586-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:15793586-Male,
pubmed-meshheading:15793586-Mice,
pubmed-meshheading:15793586-Microcephaly,
pubmed-meshheading:15793586-Microtubule-Associated Proteins,
pubmed-meshheading:15793586-Mitosis,
pubmed-meshheading:15793586-Mitotic Spindle Apparatus,
pubmed-meshheading:15793586-Molecular Sequence Data,
pubmed-meshheading:15793586-Mutation,
pubmed-meshheading:15793586-Nerve Tissue Proteins,
pubmed-meshheading:15793586-Neurons,
pubmed-meshheading:15793586-Pedigree
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pubmed:year |
2005
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pubmed:articleTitle |
A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size.
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pubmed:affiliation |
Molecular Medicine Unit, University of Leeds, St. James's University Hospital, Beckett Street, Leeds LS9 7TF, UK.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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