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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2005-5-30
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pubmed:abstractText |
Besides its predictive role in determining cardiovascular risk, C-reactive protein (CRP) may exert direct proatherogenic effects through proinflammatory properties. CRP is mainly produced by hepatocytes in response to interleukin-6 (IL-6) and is then released into the systemic circulation. 3-hydroxy-3-methylglutaryl (HMG)-coenzyme A (CoA) reductase inhibitors, or statins, significantly reduce cardiovascular events and mortality in patients with or without coronary artery disease and reduce plasma CRP levels in humans. However, the mechanism by which statins reduce plasma CRP levels remains unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/C-Reactive Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Heptanoic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Hydroxymethylglutaryl-CoA...,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Pravastatin,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrroles,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/STAT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/atorvastatin
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1231-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15790934-Anti-Inflammatory Agents,
pubmed-meshheading:15790934-C-Reactive Protein,
pubmed-meshheading:15790934-Carcinoma, Hepatocellular,
pubmed-meshheading:15790934-Cell Line, Tumor,
pubmed-meshheading:15790934-Hepatocytes,
pubmed-meshheading:15790934-Heptanoic Acids,
pubmed-meshheading:15790934-Humans,
pubmed-meshheading:15790934-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:15790934-Interleukin-6,
pubmed-meshheading:15790934-Liver Neoplasms,
pubmed-meshheading:15790934-Phosphorylation,
pubmed-meshheading:15790934-Pravastatin,
pubmed-meshheading:15790934-Protein Prenylation,
pubmed-meshheading:15790934-Pyrroles,
pubmed-meshheading:15790934-RNA, Messenger,
pubmed-meshheading:15790934-STAT3 Transcription Factor,
pubmed-meshheading:15790934-Simvastatin
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pubmed:year |
2005
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pubmed:articleTitle |
Statins reduce interleukin-6-induced C-reactive protein in human hepatocytes: new evidence for direct antiinflammatory effects of statins.
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pubmed:affiliation |
Division of Cardiology, Foundation for Medical Research, Faculty of Medicine, Geneva University Hospital, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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