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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-6-9
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pubmed:abstractText |
We have prepared polysaccharide-protein conjugates consisting of type 4 pneumococcal capsular polysaccharide (PS4) coupled to tetanus toxoid. The PS4 preparation used contained 2.5% pneumococcal cell wall polysaccharide (CPs). During the conjugation process, in addition to PS4-protein conjugates, CPs-protein conjugates were also formed. After immunization with PS4-protein conjugates, CPs-protein conjugates that are present as a contaminant induce IgG anti-CPs antibodies in mice. Pneumococcal oligosaccharides, prepared by periodate oxidation of PS4, did not contain detectable amounts of CPs; hence, oligosaccharide-protein conjugates did not induce anti-CPs antibodies.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-8584
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
181
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35-42
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pubmed:dateRevised |
2007-2-21
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pubmed:meshHeading |
pubmed-meshheading:1579084-Animals,
pubmed-meshheading:1579084-Antibodies, Bacterial,
pubmed-meshheading:1579084-Antibody Specificity,
pubmed-meshheading:1579084-Antigens, Bacterial,
pubmed-meshheading:1579084-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1579084-Female,
pubmed-meshheading:1579084-Immunoglobulin G,
pubmed-meshheading:1579084-Immunoglobulin M,
pubmed-meshheading:1579084-Mice,
pubmed-meshheading:1579084-Polysaccharides, Bacterial,
pubmed-meshheading:1579084-Streptococcus pneumoniae,
pubmed-meshheading:1579084-Tetanus Toxoid
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pubmed:year |
1992
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pubmed:articleTitle |
Induction of anti-pneumococcal cell wall polysaccharide antibodies by type 4 pneumococcal polysaccharide-protein conjugates.
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pubmed:affiliation |
Department of Immunology, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, State University, School of Medicine, Utrecht, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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