|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2005-3-25
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|
pubmed:abstractText |
The synthesis and structure-activity relationships of a novel series of substituted quercetins that activates peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. The PPARgamma agonistic activity of the most potent compound in this series is comparable to that of the thiazolidinedione-based antidiabetic drugs currently in clinical use.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0253-6269
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
28
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
142-50
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:15789741-Animals,
pubmed-meshheading:15789741-Cells, Cultured,
pubmed-meshheading:15789741-DNA, Complementary,
pubmed-meshheading:15789741-Drug Design,
pubmed-meshheading:15789741-Fibroblasts,
pubmed-meshheading:15789741-Genetic Vectors,
pubmed-meshheading:15789741-Hypoglycemic Agents,
pubmed-meshheading:15789741-Indicators and Reagents,
pubmed-meshheading:15789741-Magnetic Resonance Spectroscopy,
pubmed-meshheading:15789741-Mice,
pubmed-meshheading:15789741-PPAR gamma,
pubmed-meshheading:15789741-Plasmids,
pubmed-meshheading:15789741-Quercetin,
pubmed-meshheading:15789741-Transfection
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Design and synthesis of novel antidiabetic agents.
|
|
pubmed:affiliation |
College of Pharmacy & Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
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|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
