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pubmed-article:15788684pubmed:abstractTextRecent studies have revealed that fucose removal from the oligosaccharides of human IgG1 antibodies results in a significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) via improved IgG1 binding to FcgammaRIIIa. In this report, we investigated the relationship between enhanced ADCC and antigen density on target cells using IgG1 antibodies with reduced fucose.lld:pubmed
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pubmed-article:15788684pubmed:articleTitleEnhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen density.lld:pubmed
pubmed-article:15788684pubmed:affiliationTokyo Research Laboratories, Kyowa Hakko Kogyo, Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.lld:pubmed
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