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rdf:type |
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lifeskim:mentions |
umls-concept:C0003272,
umls-concept:C0003320,
umls-concept:C0022688,
umls-concept:C0178587,
umls-concept:C0205263,
umls-concept:C0441994,
umls-concept:C1167622,
umls-concept:C1274040,
umls-concept:C1879547,
umls-concept:C2349975,
umls-concept:C2754944
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pubmed:issue |
6
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pubmed:dateCreated |
2005-3-24
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pubmed:abstractText |
Recent studies have revealed that fucose removal from the oligosaccharides of human IgG1 antibodies results in a significant enhancement of antibody-dependent cellular cytotoxicity (ADCC) via improved IgG1 binding to FcgammaRIIIa. In this report, we investigated the relationship between enhanced ADCC and antigen density on target cells using IgG1 antibodies with reduced fucose.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD20,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD56,
http://linkedlifedata.com/resource/pubmed/chemical/CCR4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fucose,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR4,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1078-0432
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
|
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pubmed:volume |
11
|
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pubmed:owner |
NLM
|
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
2327-36
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15788684-Antibody-Dependent Cell Cytotoxicity,
pubmed-meshheading:15788684-Antigens, CD20,
pubmed-meshheading:15788684-Antigens, CD56,
pubmed-meshheading:15788684-Fucose,
pubmed-meshheading:15788684-Humans,
pubmed-meshheading:15788684-Immunoglobulin G,
pubmed-meshheading:15788684-Killer Cells, Natural,
pubmed-meshheading:15788684-Lymphoma,
pubmed-meshheading:15788684-Protein Binding,
pubmed-meshheading:15788684-Receptors, CCR4,
pubmed-meshheading:15788684-Receptors, Chemokine,
pubmed-meshheading:15788684-Tumor Cells, Cultured
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pubmed:year |
2005
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pubmed:articleTitle |
Enhanced natural killer cell binding and activation by low-fucose IgG1 antibody results in potent antibody-dependent cellular cytotoxicity induction at lower antigen density.
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pubmed:affiliation |
Tokyo Research Laboratories, Kyowa Hakko Kogyo, Co. Ltd., 3-6-6 Asahi-machi, Machida-shi, Tokyo 194-8533, Japan.
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pubmed:publicationType |
Journal Article
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