Linked Life Data

15788682

Source:http://linkedlifedata.com/resource/pubmed/id/15788682

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2005-3-24
pubmed:abstractText
c-MET is believed to be an attractive receptor target for molecular therapeutic inhibition. TPR-MET, a constitutively active oncogenic variant of MET, serves as excellent model for testing c-MET inhibitors. Here, we characterized a small molecule c-MET inhibitor, PHA665752, and tested its cooperation with the mammalian target of rapamycin inhibitor as potential targeted therapy.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1078-0432
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2312-9
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:15788682-Animals, pubmed-meshheading:15788682-Antibiotics, Antineoplastic, pubmed-meshheading:15788682-Apoptosis, pubmed-meshheading:15788682-Carcinoma, Non-Small-Cell Lung, pubmed-meshheading:15788682-Cell Cycle, pubmed-meshheading:15788682-Cell Movement, pubmed-meshheading:15788682-Cell Proliferation, pubmed-meshheading:15788682-Cell Transformation, Neoplastic, pubmed-meshheading:15788682-Drug Synergism, pubmed-meshheading:15788682-Drug Therapy, Combination, pubmed-meshheading:15788682-Humans, pubmed-meshheading:15788682-Indoles, pubmed-meshheading:15788682-Lung Neoplasms, pubmed-meshheading:15788682-Mice, pubmed-meshheading:15788682-Phosphatidylinositol 3-Kinases, pubmed-meshheading:15788682-Phosphorylation, pubmed-meshheading:15788682-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:15788682-Proto-Oncogene Proteins c-met, pubmed-meshheading:15788682-Ribosomal Protein S6 Kinases, 70-kDa, pubmed-meshheading:15788682-Signal Transduction, pubmed-meshheading:15788682-Sirolimus, pubmed-meshheading:15788682-Sulfones, pubmed-meshheading:15788682-Tumor Cells, Cultured
pubmed:year
2005
pubmed:articleTitle
A selective small molecule c-MET Inhibitor, PHA665752, cooperates with rapamycin.
pubmed:affiliation
Section of Hematology/Oncology, Department of Medicine, Pritzker School of Medicine, University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural