|
pubmed:abstractText |
It has been a long-term puzzle whether chromatin can be further divided into distinct gene expression domains. Because histone deacetylation affects chromatin structure, that in turn may affect the expression of nearby genes, histone deacetylation sites may act to partition chromatin into different gene expression domains. In this article, we explore the relationship between histone deacetylation sites and gene expression patterns on the genome scale using different data sources, including microarray data measuring gene expression levels, microarray data measuring histone deacetylation sites, and information on regulatory targets of transcription factors.
|
|
pubmed:affiliation |
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA. liang.chen@yale.edu
|
