Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2005-4-6
pubmed:abstractText
The utilisation of antitumour T cells induced by cancer vaccination with HER-2 peptides or antibodies (Herceptin) against HER-2, as immunotherapy for oesophageal cancer, is a novel and attractive approach. It is important to clarify the frequencies of HER-2 expression and gene amplification in patients with oesophageal squamous cell carcinoma (SCC) and to evaluate the relationship between HER-2 status and HLA haplotype, since the candidates for HER-2 peptide-based vaccination are restricted to a certain HLA haplotype. We determined the frequency of HER-2 expression using the HercepTest for immunohistochemistry and HER-2 gene amplification by fluorescence in situ hybridisation (FISH) assay in oesophageal SCC (n=66). HER-2-positive tumours (1+/2+/3+) analysed by a HercepTest were observed in 30.3% of all the patients and HER-2 gene amplification evaluated by FISH was observed in 11.0% of all the patients, in which all HercepTest (3+) tumours were found to have gene amplification and three of six moderately positive (2+) tumours showed gene amplification. Furthermore, HER-2-positive cells were present more diffusely and were larger within each tumour in the patients who were HercepTest 3+ than those who were HercepTest 1+. Moreover, the survival rate in HER-2-positive group was significantly worse than that in HER-2-negative group. Also, the survival rate in the patients with HER-2 gene amplification was significantly worse than that without HER-2 gene amplification. In addition, oesophageal SCC patients with both HLA-A24-positive and HER-2-positive tumours (1+/2+/3+) accounted for 26% of these cases, and both HLA-A2- and HER-2-positive tumours accounted for 18% of them.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-10389911, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-10512940, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-10561247, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-10561337, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-10964323, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-11248153, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-11689594, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-11838648, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-11850542, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-11857411, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-11948459, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-12384543, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-12429626, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-1284199, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-12860946, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-1351045, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-14630269, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-14750243, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-15073134, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-2039322, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-2210601, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-2470152, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-2565881, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-2892305, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-2999974, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-6177261, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-7539040, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-7812912, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-7902061, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-7915904, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-8092902, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-8622019, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-8669867, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-8784015, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-8988034, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-9066744, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-9754653, http://linkedlifedata.com/resource/pubmed/commentcorrection/15785739-9800975
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0007-0920
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
92
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1253-60
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15785739-Aged, pubmed-meshheading:15785739-Aged, 80 and over, pubmed-meshheading:15785739-Carcinoma, Squamous Cell, pubmed-meshheading:15785739-Esophageal Neoplasms, pubmed-meshheading:15785739-Female, pubmed-meshheading:15785739-Follow-Up Studies, pubmed-meshheading:15785739-Gene Amplification, pubmed-meshheading:15785739-Gene Expression Profiling, pubmed-meshheading:15785739-HLA Antigens, pubmed-meshheading:15785739-Haplotypes, pubmed-meshheading:15785739-Humans, pubmed-meshheading:15785739-Immunohistochemistry, pubmed-meshheading:15785739-Immunotherapy, pubmed-meshheading:15785739-In Situ Hybridization, Fluorescence, pubmed-meshheading:15785739-Male, pubmed-meshheading:15785739-Middle Aged, pubmed-meshheading:15785739-Receptor, erbB-2, pubmed-meshheading:15785739-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:15785739-Survival Analysis, pubmed-meshheading:15785739-T-Lymphocytes, pubmed-meshheading:15785739-Vaccination
pubmed:year
2005
pubmed:articleTitle
Frequencies of HER-2/neu expression and gene amplification in patients with oesophageal squamous cell carcinoma.
pubmed:affiliation
First Department of Surgery, University of Yamanashi, 1110 Tamaho, Yamanashi 409-3898, Japan.
pubmed:publicationType
Journal Article, Clinical Trial
More...