Linked Life Data

15784166

Source:http://linkedlifedata.com/resource/pubmed/id/15784166

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-3-23
pubmed:abstractText
Repair of large bone defects is still a challenge for the orthopaedic, reconstructive and maxillo-facial surgeon. Availability of pluripotent stem cells from either autologous or allogenic sources and the potential of inducing the osteogenic phenotype is motivating exploration and development of custom-tailored materials known as "bioengineered bone constructs". In such cases, the clinical scenario involves either expansion of stem cells in monolayer and loading them into a porous scaffold prior to surgery or direct cell expansion within the scaffold, and implanting this novel construct back into the donor patient. In this review, we delineate, from an engineering perspective, the progress that has been made to date and the challenges remaining in successfully translating this promising (but not yet definitively established) approach from bench to the bed site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1582-1838
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
72-84
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:articleTitle
Engineering bone: challenges and obstacles.
pubmed:affiliation
Laboratoire de Recherches Orthopédiques, Faculté de Médecine Lariboisière Saint-Louis, Université Denis Diderot, Paris, France.
pubmed:publicationType
Journal Article, Review