pubmed-article:1578240 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C0020094 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C0030481 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C0474643 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C1707520 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C2346689 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C1550025 | lld:lifeskim |
pubmed-article:1578240 | lifeskim:mentions | umls-concept:C0598148 | lld:lifeskim |
pubmed-article:1578240 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:1578240 | pubmed:dateCreated | 1992-6-9 | lld:pubmed |
pubmed-article:1578240 | pubmed:abstractText | We studied the relationship between antibody titers to recombinant HTLV-I p40tax protein and gag-env hybrid protein in serum (by an enzyme-linked immunosorbent assay) and HTLV-I proviral DNA load in peripheral blood mononuclear cells (by a quantitative polymerase chain reaction method) in 18 patients with HTLV-I-associated myelopathy (HAM)/tropical spastic paraparesis (TSP), 17 HTLV-I carriers without HAM/TSP and 16 HTLV-I uninfected controls. The IgG and IgA antibody titers to either of the proteins correlated significantly with the HTLV-I pX (coding p40tax protein) and pol DNA amounts in HTLV-I infected subjects. HAM/TSP patients had significantly higher titers of IgG and IgA antibodies to the HTLV-I proteins than did the HTLV-I carriers without HAM/TSP. While the IgM antibodies to the HTLV-I proteins were found in only 6% of HTLV-I carriers without HAM/TSP, they were found in 40% of HAM/TSP patients, especially those having both a high HTLV-I proviral DNA load and high titers of the IgG and IgA antibodies. HAM/TSP patients with the IgM antibodies had a tendency to deteriorate more frequently on the Kurtzke's disability status scale and magnetic resonance imaging of the brain (leukoencephalopathy) than did those without in the two-year follow-up. Thus, the presence of IgM antibody and high titers of IgG and IgA antibodies to the HTLV-I proteins, together with the increased HTLV-I proviral DNA load, appears to distinguish HAM/TSP patients from HTLV-I carriers without HAM/TSP. | lld:pubmed |
pubmed-article:1578240 | pubmed:language | eng | lld:pubmed |
pubmed-article:1578240 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1578240 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:1578240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1578240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:1578240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1578240 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:1578240 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:1578240 | pubmed:month | Jan | lld:pubmed |
pubmed-article:1578240 | pubmed:issn | 0022-510X | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:NakamuraMM | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:SakakiYY | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:GotoII | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:YamamotoNN | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:ItoyamaYY | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:SawadaTT | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:KiraJJ | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:KoyanagiYY | lld:pubmed |
pubmed-article:1578240 | pubmed:author | pubmed-author:OhoriNN | lld:pubmed |
pubmed-article:1578240 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:1578240 | pubmed:volume | 107 | lld:pubmed |
pubmed-article:1578240 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:1578240 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:1578240 | pubmed:pagination | 98-104 | lld:pubmed |
pubmed-article:1578240 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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pubmed-article:1578240 | pubmed:year | 1992 | lld:pubmed |
pubmed-article:1578240 | pubmed:articleTitle | Antibody titers to HTLV-I-p40tax protein and gag-env hybrid protein in HTLV-I-associated myelopathy/tropical spastic paraparesis: correlation with increased HTLV-I proviral DNA load. | lld:pubmed |
pubmed-article:1578240 | pubmed:affiliation | Department of Neurology, Kyushu University, Fukuoka, Japan. | lld:pubmed |
pubmed-article:1578240 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:1578240 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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