Source:http://linkedlifedata.com/resource/pubmed/id/15782344
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
9
|
| pubmed:dateCreated |
2005-8-3
|
| pubmed:abstractText |
We report a 36-year-old male with myeloid/natural killer (NK)-cell precursor acute leukaemia with a complex aberrant karyotype, who was treated according to an acute-myeloid-leukaemia (AML) treatment protocol (idarubicine, cytarabine, and etoposide) followed by high-dose cytarabine consolidation and achieved complete remission. He underwent allogeneic matched unrelated donor (MUD) peripheral blood stem-cell transplantation (PBSCT) and remained in remission throughout his remaining life. Seven months posttransplantation, a myelodysplastic syndrome (MDS) with (20q-) of donor origin was diagnosed causing severe thrombocytopenia and finally leading to infection and death. This patient represents one of the few cases published achieving remission for a significant period of time after being diagnosed with myeloid/NK-cell precursor acute leukaemia, a very rare malignant disease. We conclude, despite the fatal outcome due to infection, that allogeneic PBSCT is a therapeutic option for patients with this entity. In addition, the development of a myelodysplastic syndrome of donor origin is extremely rare and only very few cases are published worldwide.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Sep
|
| pubmed:issn |
0939-5555
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
84
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
616-8
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15782344-Acute Disease,
pubmed-meshheading:15782344-Adult,
pubmed-meshheading:15782344-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15782344-Disease-Free Survival,
pubmed-meshheading:15782344-Fatal Outcome,
pubmed-meshheading:15782344-Humans,
pubmed-meshheading:15782344-Infection,
pubmed-meshheading:15782344-Killer Cells, Natural,
pubmed-meshheading:15782344-Leukemia, Myeloid,
pubmed-meshheading:15782344-Leukemia, Prolymphocytic, T-Cell,
pubmed-meshheading:15782344-Male,
pubmed-meshheading:15782344-Myelodysplastic Syndromes,
pubmed-meshheading:15782344-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:15782344-Remission Induction,
pubmed-meshheading:15782344-Thrombocytopenia,
pubmed-meshheading:15782344-Tissue Donors,
pubmed-meshheading:15782344-Transplantation, Homologous,
pubmed-meshheading:15782344-Treatment Outcome
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
Myelodysplastic syndrome of donor origin subsequent to successful treatment of myeloid/NK-cell precursor leukaemia with allogeneic PBSCT: two very rare conditions in one patient.
|
| pubmed:publicationType |
Letter,
Case Reports
|