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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-22
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pubmed:abstractText |
Pancreatic fibrosis is a characteristic feature of chronic pancreatic injury, which is a result of the imbalance between synthesis and degradation of extracellular matrix (ECM) proteins. Transforming growth factor-beta (TGF-beta) plays a central role in biosynthesis and turnover of the ECM. In this study, we evaluated the role of TGF-beta signaling in pancreatic fibrosis induced by repetitive acute pancreatic injuries with mice of dominant-negative mutant of TGF-beta receptor II selectively in pancreas.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Caerulein,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Transforming Growth...,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factor AP-1,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/transforming growth factor-beta...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1536-4828
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e71-9
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15782092-Animals,
pubmed-meshheading:15782092-Caerulein,
pubmed-meshheading:15782092-Cells, Cultured,
pubmed-meshheading:15782092-Extracellular Matrix Proteins,
pubmed-meshheading:15782092-Fibrosis,
pubmed-meshheading:15782092-Male,
pubmed-meshheading:15782092-Mice,
pubmed-meshheading:15782092-Mice, Inbred Strains,
pubmed-meshheading:15782092-Mice, Transgenic,
pubmed-meshheading:15782092-NF-kappa B,
pubmed-meshheading:15782092-Pancreas,
pubmed-meshheading:15782092-Pancreatitis, Chronic,
pubmed-meshheading:15782092-Protein-Serine-Threonine Kinases,
pubmed-meshheading:15782092-Receptors, Transforming Growth Factor beta,
pubmed-meshheading:15782092-Signal Transduction,
pubmed-meshheading:15782092-Transcription, Genetic,
pubmed-meshheading:15782092-Transcription Factor AP-1,
pubmed-meshheading:15782092-Transfection,
pubmed-meshheading:15782092-Transforming Growth Factor beta,
pubmed-meshheading:15782092-Transforming Growth Factor beta1
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pubmed:year |
2005
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pubmed:articleTitle |
Amelioration of pancreatic fibrosis in mice with defective TGF-beta signaling.
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pubmed:affiliation |
Genome Research Center for Gastroenterology, Department of Gastroenterology, Ajou University School of Medicine, Suwon, Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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