Linked Life Data

15781986

Source:http://linkedlifedata.com/resource/pubmed/id/15781986

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-3-22
pubmed:abstractText
Keratinocyte growth factor (KGF), a mesenchymal cell derived paracrine growth factor that regulates normal epithelial cell proliferation, appears to be an essential mediator of steroids in various reproductive organs. The present study was designed to determine the expression and role of KGF and its receptor (KGFR) in human breast carcinoma tissues by immunohistochemistry. We also compared the results with the expression of estrogen receptor alpha(ERalpha), ERbeta, the proliferative activity assessed by the labeling index (LI) for the Ki-67 antigen, apoptotic frequency assessed by terminal dUTP nick end-labeling (TUNEL) index, and the expression of Bcl-2. All of KGF-positive cases were ERalpha- positive (p<0.05), but not that of ERbeta, while all of KGFR-positive cases were ERbeta-positive (p<0.05), but not that of ERalpha. The specimens with the coexpression of KGF and KGFR significantly correlated with a lower TUNEL index (p<0.05), but not with Ki-67 LI in breast cancer tissues. Further analysis at the cellular level revealed that Bcl-2 was colocalized in KGFR-positive cells, and these cells were almost negative for TUNEL staining. Bcl-2-positive cells were also associated with ERbeta, as expected. Therefore, the results indicate that ERalpha may be involved in KGF expression, and that the coexpression of KGF and KGFR may play an inhibitory role in the induction of apoptosis possibly through the up-regulation of Bcl-2 expression in human breast cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0914-9465
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
455-64
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:15781986-Adult, pubmed-meshheading:15781986-Aged, pubmed-meshheading:15781986-Apoptosis, pubmed-meshheading:15781986-Breast Neoplasms, pubmed-meshheading:15781986-Carcinoma, Ductal, Breast, pubmed-meshheading:15781986-Carcinoma, Lobular, pubmed-meshheading:15781986-Cell Proliferation, pubmed-meshheading:15781986-Estrogen Receptor alpha, pubmed-meshheading:15781986-Estrogen Receptor beta, pubmed-meshheading:15781986-Female, pubmed-meshheading:15781986-Fibroblast Growth Factor 7, pubmed-meshheading:15781986-Fibroblast Growth Factors, pubmed-meshheading:15781986-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15781986-Humans, pubmed-meshheading:15781986-Immunohistochemistry, pubmed-meshheading:15781986-Keratinocytes, pubmed-meshheading:15781986-Ki-67 Antigen, pubmed-meshheading:15781986-Middle Aged, pubmed-meshheading:15781986-Proto-Oncogene Proteins c-bcl-2, pubmed-meshheading:15781986-Receptor, Fibroblast Growth Factor, Type 2, pubmed-meshheading:15781986-Receptors, Fibroblast Growth Factor
pubmed:year
2004
pubmed:articleTitle
Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2.
pubmed:affiliation
Division of Histology and Cell Biology, Department of Developmental and Reconstructive Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't