Linked Life Data

15781984

Source:http://linkedlifedata.com/resource/pubmed/id/15781984

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-3-22
pubmed:abstractText
Estrogen has crucial roles in the proliferation of cancer cells in reproductive organs such as the breast and uterus. Estrogen-stimulated growth requires two estrogen receptors (ERalpha and ERbeta) which are ligand-dependent transcription factors. High expression of ERs is observed in a large population of breast tumors. In addition, the positive expression of ERs correlates with well-differentiated tumors, a favorable prognosis, and responsiveness to an endocrine therapy with anti-estrogen drugs in patients with breast cancer. Transcription activities of ERs can be regulated by interacting proteins such as coactivators and kinases as well as ligand-binding. Moreover, ER isoforms lacking an ability to transactivate are involved in breast cancer. Downstream target genes of ERs have important roles in mediating the estrogen action in breast cancer. We have isolated and characterized several novel estrogen-responsive genes to clarify the molecular mechanism of the estrogen action in target cells. Among these genes, the estrogen-responsive finger protein (Efp) was found to be highly expressed in breast cancer. Efp as a ubiquitin ligase (E3) is involved in the proteasome-dependent degradation of the 14-3-3sigma protein, one of cell cycle brakes, this degradation resulting in the promotion of breast cancer growth. A full understanding of the expression and function of ERs and their target genes could shed light on how estrogen stimulates the initiation and promotion of cancer, providing a new approach to diagnose and treat cancer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0914-9465
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
435-42
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed-meshheading:15781984-14-3-3 Proteins, pubmed-meshheading:15781984-Animals, pubmed-meshheading:15781984-Breast Neoplasms, pubmed-meshheading:15781984-Estrogen Receptor Modulators, pubmed-meshheading:15781984-Estrogen Receptor alpha, pubmed-meshheading:15781984-Estrogen Receptor beta, pubmed-meshheading:15781984-Female, pubmed-meshheading:15781984-Gene Expression Regulation, Neoplastic, pubmed-meshheading:15781984-Humans, pubmed-meshheading:15781984-Ligands, pubmed-meshheading:15781984-Models, Biological, pubmed-meshheading:15781984-Proteasome Endopeptidase Complex, pubmed-meshheading:15781984-Receptors, Estrogen, pubmed-meshheading:15781984-Selective Estrogen Receptor Modulators, pubmed-meshheading:15781984-Structure-Activity Relationship, pubmed-meshheading:15781984-Transcription, Genetic, pubmed-meshheading:15781984-Ubiquitin-Protein Ligases
pubmed:year
2004
pubmed:articleTitle
Estrogen receptors and their downstream targets in cancer.
pubmed:affiliation
Division of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical School, 1397-1 Yamane, Hidaka-shi, Saitama 350-1241, USA.
pubmed:publicationType
Journal Article, Review