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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2005-3-22
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pubmed:abstractText |
Various new tuberculosis (TB) vaccine candidates in combination with new delivery systems, including subunit vaccines, are currently being evaluated by a number of laboratories. One vaccine candidate that has shown promising protective capacity in mice and guinea pigs is a fusion of Ag85B and ESAT-6. In this study, we have investigated the efficacy of this Ag85B-ESAT-6 fusion protein vaccine in a non-human primate model for TB. Vaccination of cynomolgus monkeys with the Ag85B-ESAT-6 fusion protein in two different adjuvant (DDA/MPL, AS02A) resulted in a reduction in bacterial number and/or lung pathology in animals challenged with Mycobacterium tuberculosis. Vaccination prevented an increase in C-reactive protein serum levels, general activation of CD4 and CD8 subsets and boosted development of humoral and cellular immune responses to a spectrum of mycobacterial antigens on exposure to M. tuberculosis infection. We show, in two independent experiments, that vaccination of primates with Ag85B-ESAT-6 induces protective immune responses, suggesting that Ag85B-ESAT-6 is a strong candidate for further clinical evaluation. As far as we are aware this is the first report of protection in primates with a subunit vaccine.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/ESAT-6 protein, Mycobacterium...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Tuberculosis Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Synthetic,
http://linkedlifedata.com/resource/pubmed/chemical/antigen 85B, Mycobacterium...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-410X
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pubmed:author |
pubmed-author:AagaardClausC,
pubmed-author:AggerElse MarieEM,
pubmed-author:AndersenPeterP,
pubmed-author:DalemansWilfriedW,
pubmed-author:DohertyT MarkTM,
pubmed-author:GreenwaldRenaR,
pubmed-author:LangermansJan A MJA,
pubmed-author:LyashchenkoKonstantinK,
pubmed-author:ThomasAlan WAW,
pubmed-author:VervenneRichard A WRA,
pubmed-author:WeilerHorstH,
pubmed-author:van SoolingenDickD,
pubmed-author:van der LaanTridiaT
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2740-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15780721-Acyltransferases,
pubmed-meshheading:15780721-Animals,
pubmed-meshheading:15780721-Antibodies, Bacterial,
pubmed-meshheading:15780721-Antigens, Bacterial,
pubmed-meshheading:15780721-Bacterial Proteins,
pubmed-meshheading:15780721-CD4-CD8 Ratio,
pubmed-meshheading:15780721-Interferon-gamma,
pubmed-meshheading:15780721-Macaca fascicularis,
pubmed-meshheading:15780721-Male,
pubmed-meshheading:15780721-Recombinant Fusion Proteins,
pubmed-meshheading:15780721-Tuberculosis,
pubmed-meshheading:15780721-Tuberculosis Vaccines,
pubmed-meshheading:15780721-Vaccination,
pubmed-meshheading:15780721-Vaccines, Subunit,
pubmed-meshheading:15780721-Vaccines, Synthetic
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pubmed:year |
2005
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pubmed:articleTitle |
Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6.
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pubmed:affiliation |
Department of Parasitology, Biomedical Primate Research Centre, P.O. Box 3306, 2280 GH Rijswijk, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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