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pubmed-article:15780616pubmed:abstractTextA series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described.lld:pubmed
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pubmed-article:15780616pubmed:articleTitleFused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.lld:pubmed
pubmed-article:15780616pubmed:affiliationBristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. james.kempson@bms.comlld:pubmed
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