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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-3-22
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pubmed:abstractText |
A series of fused pyrimidine based inhibitors of PDE7 have been derived from an earlier screening lead 1. The synthesis, structure-activity relationships (SAR) and selectivity against several other PDE family members are described.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BarbosaJosephJ,
pubmed-author:BarrishJoel CJC,
pubmed-author:DoddJohn HJH,
pubmed-author:FelixRaymondR,
pubmed-author:FischerKarlK,
pubmed-author:GuoJunqingJ,
pubmed-author:KempsonJamesJ,
pubmed-author:OmotosoOmonikeO,
pubmed-author:PittsWilliam JWJ,
pubmed-author:StarlingGary CGC,
pubmed-author:StebbinsKarenK,
pubmed-author:WatsonAndrewA
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1829-33
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:15780616-3',5'-Cyclic-AMP Phosphodiesterases,
pubmed-meshheading:15780616-Cell Line,
pubmed-meshheading:15780616-Cyclic Nucleotide Phosphodiesterases, Type 7,
pubmed-meshheading:15780616-Humans,
pubmed-meshheading:15780616-Inhibitory Concentration 50,
pubmed-meshheading:15780616-Isoenzymes,
pubmed-meshheading:15780616-Phosphodiesterase Inhibitors,
pubmed-meshheading:15780616-Pyrimidines,
pubmed-meshheading:15780616-Structure-Activity Relationship
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pubmed:year |
2005
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pubmed:articleTitle |
Fused pyrimidine based inhibitors of phosphodiesterase 7 (PDE7): synthesis and initial structure-activity relationships.
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pubmed:affiliation |
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA. james.kempson@bms.com
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pubmed:publicationType |
Journal Article
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