Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-6-11
|
| pubmed:abstractText |
Chronic microaspiration through a tracheal cuff is the main culprit in the penetration and colonization of the lower respiratory tract. A total of 145 patients intubated for more than 3 days were randomly assigned to a double nosocomial pneumonia (NP) prevention: 1--Prevention of aspiration by hourly subglottic secretion drainage (SSD) with a specific endotracheal tube (HI-LO Evac tube, Mallinckrodt); 2--Prevention of gastric colonization using either sucralfate or antacids. Four random groups were defined, similar in age and severity of illness. Subglottic secretion drainage treatment was associated with: a) a twice lower incidence of NP (no-SSD: 29.1%, SSD: 13%); b) a prolonged time of onset of NP (no-SSD: 8.3 +/- 5 days, SSD: 16.2 +/- 11 days); c) a decrease in the colonization rate from admission to end-point day in tracheal aspirates (no-SSD: +21.3%, SSD: +6.6%) and in subglottic secretions (no-SSD: +33.4%, SSD: +2.1%). Sucralfate was not associated with a significantly lower incidence of NP (antacids: 23.6%, sucralfate: 17.8%), but with a lower increase in the colonization rate in subglottic and gastric aspirates, from admission to end-point day.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0342-4642
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
18
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
20-5
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1578042-Adult,
pubmed-meshheading:1578042-Aged,
pubmed-meshheading:1578042-Antacids,
pubmed-meshheading:1578042-Colony Count, Microbial,
pubmed-meshheading:1578042-Cross Infection,
pubmed-meshheading:1578042-Decision Trees,
pubmed-meshheading:1578042-Female,
pubmed-meshheading:1578042-France,
pubmed-meshheading:1578042-Gastric Acidity Determination,
pubmed-meshheading:1578042-Humans,
pubmed-meshheading:1578042-Incidence,
pubmed-meshheading:1578042-Infection,
pubmed-meshheading:1578042-Intensive Care Units,
pubmed-meshheading:1578042-Intubation, Intratracheal,
pubmed-meshheading:1578042-Male,
pubmed-meshheading:1578042-Middle Aged,
pubmed-meshheading:1578042-Peptic Ulcer,
pubmed-meshheading:1578042-Pneumonia, Aspiration,
pubmed-meshheading:1578042-Stomach Diseases,
pubmed-meshheading:1578042-Stress, Psychological,
pubmed-meshheading:1578042-Sucralfate,
pubmed-meshheading:1578042-Suction,
pubmed-meshheading:1578042-Treatment Outcome
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Prevention of nosocomial pneumonia in intubated patients: respective role of mechanical subglottic secretions drainage and stress ulcer prophylaxis.
|
| pubmed:affiliation |
Service de Réanimation Polyvalente, Hôpital Nord, CHRU St. Etienne, France.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|