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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6184
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pubmed:dateCreated |
1979-11-21
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pubmed:abstractText |
A patient with rheumatoid arthritis developed severe exacerbation of symptoms 18 hours after an injection of gold thiomalate (sodium aurothiomalate). Immune complexes were present in his serum and synovial fluid; in the synovial fluid they were associated with intense complement activation. The effect of gold salts on splenic reticuloendothelial function was determined by measuring the clearance of heat-damaged erythrocytes from the circulation. Gold thiomalate (50 mg) substantially delayed clearance in the patient but had no effect in four other patients with rheumatoid arthritis who had not had a postinjection reaction. Severely impaired clearance also occurred in three out of four healthy people given 100 mg gold but they remained asymptomatic. The postinjection reaction may be an immune-complex disease that is triggered in certain patients because gold transiently inhibits reticuloendothelial function.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-101463,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-1087551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-1141431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-152806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-403043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-406862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-409414,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-4401248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-4580005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-4599389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-4992981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-5169615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-5416098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-5579191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-79721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-838859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-944196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/157793-977786
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0007-1447
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
235-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1979
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pubmed:articleTitle |
Inhibition of reticuloendothelial function by gold and its relation to postinjection reactions.
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pubmed:publicationType |
Journal Article,
Case Reports
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