Linked Life Data

1577842

Source:http://linkedlifedata.com/resource/pubmed/id/1577842

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2 Pt 2
pubmed:dateCreated
1992-6-11
pubmed:abstractText
At the time that methicillin-resistant Staphylococcus aureus (MRSA) began to achieve clinical prominence, it was thought to be spread by exogenous vectors. Institution of rigorous infection control efforts, including isolation procedures, was found to have little effect on the frequency of MRSA colonization of burn wounds. It was later found that handwashing was sufficient to prevent cross-contamination. Subsequently, it has been shown that patients can be harboring MRSA at the time of admission to the burn unit and that multiple antimicrobial resistance can develop among organisms that reside in the patient through plasmid-mediated transfer of resistance genes. Excessive use of such agents as the synthetic penicillins and second- and third-generation cephalosporins has selected for the survival of these organisms. Currently, the only available agent for systemic treatment of MRSA infection is vancomycin, the use of which is expensive and associated with significant toxicity. Muciprocin is a topical antimicrobial that promises to be useful in the treatment of such infections. Other agents for systemic use are needed, since use of a single drug to combat MRSA infections seems likely to encourage the emergence of resistant organisms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0273-8481
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
293-7
pubmed:dateRevised
2006-8-15
pubmed:meshHeading
pubmed:articleTitle
Burn and trauma units as sources of methicillin-resistant Staphylococcus aureus.
pubmed:affiliation
Division of Plastic Surgery, University of Texas Medical Branch, Galveston 77550.
pubmed:publicationType
Journal Article, Review