| pubmed-article:15778343 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C0025260 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C0054950 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C1332714 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C1456796 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C1420812 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C1705984 | lld:lifeskim |
| pubmed-article:15778343 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:15778343 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15778343 | pubmed:dateCreated | 2005-3-21 | lld:pubmed |
| pubmed-article:15778343 | pubmed:abstractText | Recently, we reported that a CD4(+)CD3(-)CD11c(-) accessory cell provided OX40-dependent survival signals to follicular T cells. These accessory cells express both OX40 ligand and CD30 ligand, and the receptors, OX40 and CD30, are both expressed on Th2-primed CD4 T cells. OX40 and CD30 signals share common signaling pathways, suggesting that CD30 signals might substantially compensate in OX40-deficient mice. In this report we have dissected the signaling roles of CD30 alone and in combination with OX40. CD30-deficient mice showed an impaired capacity to sustain follicular germinal center responses, and recall memory Ab responses were substantially reduced. Deficiencies in OX40 and CD30 signals were additive; secondary Ab responses were ablated in double-deficient mice. Although the initial proliferation of OX40/CD30 double-knockout OTII transgenic T cells was comparable to that of their normal counterparts, they failed to survive in vivo, and this was associated with reduced T cell numbers associated with CD4(+)CD3(-) cells in B follicles. Finally, we show that OX40/CD30 double-knockout OTII transgenic T cells fail to survive compared with normal T cells when cocultured with CD4(+)CD3(-) cells in vitro. | lld:pubmed |
| pubmed-article:15778343 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15778343 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15778343 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15778343 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:15778343 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15778343 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15778343 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15778343 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:15778343 | pubmed:author | pubmed-author:KimMi-YeonMY | lld:pubmed |
| pubmed-article:15778343 | pubmed:author | pubmed-author:GaspalFabrina... | lld:pubmed |
| pubmed-article:15778343 | pubmed:author | pubmed-author:LanePeter J... | lld:pubmed |
| pubmed-article:15778343 | pubmed:author | pubmed-author:McConnellFion... | lld:pubmed |
| pubmed-article:15778343 | pubmed:author | pubmed-author:RaykundaliaCh... | lld:pubmed |
| pubmed-article:15778343 | pubmed:author | pubmed-author:BekiarisVasil... | lld:pubmed |
| pubmed-article:15778343 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15778343 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:15778343 | pubmed:volume | 174 | lld:pubmed |
| pubmed-article:15778343 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15778343 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15778343 | pubmed:pagination | 3891-6 | lld:pubmed |
| pubmed-article:15778343 | pubmed:dateRevised | 2007-8-13 | lld:pubmed |
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| pubmed-article:15778343 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15778343 | pubmed:articleTitle | Mice deficient in OX40 and CD30 signals lack memory antibody responses because of deficient CD4 T cell memory. | lld:pubmed |
| pubmed-article:15778343 | pubmed:affiliation | Medical Research Council Center for Immune Regulation, Institute for Biomedical Research, Birmingham Medical School, Birmingham, United Kingdom. | lld:pubmed |
| pubmed-article:15778343 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15778343 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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