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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2005-4-4
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pubmed:abstractText |
As part of an ongoing search for genes associated with type 1 diabetes (T1D), a common autoimmune disease, we tested the biological candidate gene IL2RA (CD25), which encodes a subunit (IL-2R alpha) of the high-affinity interleukin-2 (IL-2) receptor complex. We employed a tag single-nucleotide polymorphism (tag SNP) approach in large T1D sample collections consisting of 7,457 cases and controls and 725 multiplex families. Tag SNPs were analyzed using a multilocus test to provide a regional test for association. We found strong statistical evidence in the case-control collection (P=6.5x10(-8)) for a T1D locus in the CD25 region of chromosome 10p15 and replicated the association in the family collection (P=7.3x10(-3); combined P=1.3x10(-10)). These results illustrate the utility of tag SNPs in a chromosome-regional test of disease association and justify future fine mapping of the causal variant in the region.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/15776395-10795741,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0002-9297
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pubmed:author |
pubmed-author:ClaytonDavid GDG,
pubmed-author:CooperJason DJD,
pubmed-author:DungerDavid BDB,
pubmed-author:JonesRichardR,
pubmed-author:LoweChristopher ECE,
pubmed-author:McArdleWendyW,
pubmed-author:NutlandSarahS,
pubmed-author:PembreyMarcus EME,
pubmed-author:RingSusan MSM,
pubmed-author:StrachanDavid PDP,
pubmed-author:ToddJohn AJA,
pubmed-author:TwellsRebecca C JRC,
pubmed-author:VellaAdrianA,
pubmed-author:WalkerNeilN,
pubmed-author:WidmerBarryB
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
773-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:15776395-Case-Control Studies,
pubmed-meshheading:15776395-Diabetes Mellitus, Type 1,
pubmed-meshheading:15776395-Female,
pubmed-meshheading:15776395-Genetic Predisposition to Disease,
pubmed-meshheading:15776395-Humans,
pubmed-meshheading:15776395-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:15776395-Linkage Disequilibrium,
pubmed-meshheading:15776395-Male,
pubmed-meshheading:15776395-Odds Ratio,
pubmed-meshheading:15776395-Polymorphism, Single Nucleotide,
pubmed-meshheading:15776395-Receptors, Interleukin
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pubmed:year |
2005
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pubmed:articleTitle |
Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.
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pubmed:affiliation |
Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, Wellcome Trust/Medical Research Council Building, Addenbrooke's Hospital, Cambridge, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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