| pubmed-article:15775970 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C1179889 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C1826618 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C0234402 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
| pubmed-article:15775970 | lifeskim:mentions | umls-concept:C0699789 | lld:lifeskim |
| pubmed-article:15775970 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:15775970 | pubmed:dateCreated | 2005-5-19 | lld:pubmed |
| pubmed-article:15775970 | pubmed:abstractText | Apoptosis-inducing factor (AIF) is a mitochondrial intermembrane flavoprotein that is translocated to the nucleus in response to proapoptotic stimuli, where it induces nuclear apoptosis. Here we show that AIF is synthesized as an approximately 67-kDa preprotein with an N-terminal extension and imported into mitochondria, where it is processed to the approximately 62-kDa mature form. Topology analysis revealed that mature AIF is a type-I inner membrane protein with the N-terminus exposed to the matrix and the C-terminal portion to the intermembrane space. Upon induction of apoptosis, processing of mature AIF to an approximately 57-kDa form occurred caspase-independently in the intermembrane space, releasing the processed form into the cytoplasm. Bcl-2 or Bcl-XL inhibited both these events. These findings indicate that AIF release from mitochondria occurs by a two-step process: detachment from the inner membrane by apoptosis-induced processing in the intermembrane space and translocation into the cytoplasm. The results also suggest the presence of a unique protease that is regulated by proapoptotic stimuli in caspase-independent cell death. | lld:pubmed |
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| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:language | eng | lld:pubmed |
| pubmed-article:15775970 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:15775970 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:15775970 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:15775970 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:15775970 | pubmed:author | pubmed-author:OteraHidenori... | lld:pubmed |
| pubmed-article:15775970 | pubmed:author | pubmed-author:MiharaKatsuyo... | lld:pubmed |
| pubmed-article:15775970 | pubmed:author | pubmed-author:IshiharaNaota... | lld:pubmed |
| pubmed-article:15775970 | pubmed:author | pubmed-author:OhsakayaShige... | lld:pubmed |
| pubmed-article:15775970 | pubmed:author | pubmed-author:NagauraZen-Ic... | lld:pubmed |
| pubmed-article:15775970 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:15775970 | pubmed:day | 6 | lld:pubmed |
| pubmed-article:15775970 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:15775970 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:15775970 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:15775970 | pubmed:pagination | 1375-86 | lld:pubmed |
| pubmed-article:15775970 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:15775970 | pubmed:meshHeading | pubmed-meshheading:15775970... | lld:pubmed |
| pubmed-article:15775970 | pubmed:meshHeading | pubmed-meshheading:15775970... | lld:pubmed |
| pubmed-article:15775970 | pubmed:meshHeading | pubmed-meshheading:15775970... | lld:pubmed |
| pubmed-article:15775970 | pubmed:meshHeading | pubmed-meshheading:15775970... | lld:pubmed |
| pubmed-article:15775970 | pubmed:meshHeading | pubmed-meshheading:15775970... | lld:pubmed |
| pubmed-article:15775970 | pubmed:meshHeading | pubmed-meshheading:15775970... | lld:pubmed |
| pubmed-article:15775970 | pubmed:year | 2005 | lld:pubmed |
| pubmed-article:15775970 | pubmed:articleTitle | Export of mitochondrial AIF in response to proapoptotic stimuli depends on processing at the intermembrane space. | lld:pubmed |
| pubmed-article:15775970 | pubmed:affiliation | Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan. | lld:pubmed |
| pubmed-article:15775970 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:15775970 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:15775970 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
