Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2005-5-19
pubmed:abstractText
Bloom's syndrome (BS) is a rare human genetic disorder characterized by dwarfism, immunodeficiency, genomic instability and cancer predisposition. We have previously purified three complexes containing BLM, the helicase mutated in this disease. Here we demonstrate that BLAP75, a novel protein containing a putative OB-fold nucleic acid binding domain, is an integral component of BLM complexes, and is essential for their stability in vivo. Consistent with a role in BLM-mediated processes, BLAP75 colocalizes with BLM in subnuclear foci in response to DNA damage, and its depletion impairs the recruitment of BLM to these foci. Depletion of BLAP75 by siRNA also results in deficient phosphorylation of BLM during mitosis, as well as defective cell proliferation. Moreover, cells depleted of BLAP75 display an increased level of sister-chromatid exchange, similar to cells depleted of BLM by siRNA. Thus, BLAP75 is an essential component of the BLM-associated cellular machinery that maintains genome integrity.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-10319867, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-10783165, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-10823897, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-10825162, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-10851073, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11087418, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11278509, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11325959, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11399766, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11406610, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11418864, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11454428, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11470874, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-11691925, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-12034743, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-12062168, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-12445391, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-12598368, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-12803543, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-12953102, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-12967657, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-1339306, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-14517203, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-14670619, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-14685245, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-15184880, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-15197177, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-15502827, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-15525939, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-4138930, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-4140506, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-5770175, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-6888276, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-7585968, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-8231788, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-8602509, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-868871, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-9388193, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-9448276, http://linkedlifedata.com/resource/pubmed/commentcorrection/15775963-9765292
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0261-4189
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1465-76
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
More...