Linked Life Data

15775643

Source:http://linkedlifedata.com/resource/pubmed/id/15775643

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2005-3-18
pubmed:abstractText
In the kidney, reabsorption of filtered inorganic phosphate (Pi) takes place along the proximal tubules and is controlled by a variety of hormones (e.g.parathyroid hormone, PTH). Three structurally unrelated sodium-dependent phosphate (Na/Pi) cotransporter families have been identified. Targeted inactivation of the type IIa Na/Pi cotransporter gene (npt2) provided strong evidence that - 70% of Na-dependent Pi transport across the brush border membrane is mediated by the type IIa Na/Pi cotransporter. The type IIa cotransporter represents the major target for PTH. The type IIa cotransporter interacts with various PDZ proteins that might be responsible for the apical sorting, PTH controlled endocytosis or the lysosomal sorting internalized type IIa cotransporter.
pubmed:language
jpn
pubmed:journal
pubmed:status
PubMed-not-MEDLINE
pubmed:month
Oct
pubmed:issn
0917-5857
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1297-301
pubmed:dateRevised
2006-11-15
pubmed:year
2001
pubmed:articleTitle
[Cellular mechanisms in proximal tubular handling of phosphate].
pubmed:affiliation
Dept of Nutrition, School of Medicine, Tokushima University.
pubmed:publicationType
Journal Article, English Abstract