|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0013216,
umls-concept:C0030705,
umls-concept:C0033095,
umls-concept:C0144576,
umls-concept:C0162367,
umls-concept:C0205210,
umls-concept:C0282636,
umls-concept:C0332161,
umls-concept:C0332293,
umls-concept:C0547047,
umls-concept:C0600558
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2005-3-18
|
|
pubmed:abstractText |
It has been hypothesized that tumors with high interstitial fluid pressure (IFP) and/or hypoxia respond poorly to chemotherapy (CT) because of poor drug delivery. Preclinical studies have shown that paclitaxel reduces the IFP and improves the oxygenation (pO(2)) of tumors. Our aim is to evaluate the IFP and pO(2) before and after neoadjuvant CT using sequential paclitaxel and doxorubicin in patients with breast cancer tumors of >/= 3 cm.
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pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0732-183X
|
|
pubmed:author |
pubmed-author:Abi-RaadRitaR,
pubmed-author:AncukiewiczMarekM,
pubmed-author:AssaadSherif ISI,
pubmed-author:AttiaKhaledK,
pubmed-author:BoucherYvesY,
pubmed-author:CastyAdrianA,
pubmed-author:KuterIreneI,
pubmed-author:MolokhiaPeryhanP,
pubmed-author:PowellSimon NSN,
pubmed-author:SullivanTimothyT,
pubmed-author:TaghianAlphonse GAG,
pubmed-author:YehErenE
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
20
|
|
pubmed:volume |
23
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1951-61
|
|
pubmed:dateRevised |
2007-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:15774788-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:15774788-Breast Neoplasms,
pubmed-meshheading:15774788-Chemotherapy, Adjuvant,
pubmed-meshheading:15774788-Doxorubicin,
pubmed-meshheading:15774788-Drug Administration Schedule,
pubmed-meshheading:15774788-Extracellular Fluid,
pubmed-meshheading:15774788-Female,
pubmed-meshheading:15774788-Humans,
pubmed-meshheading:15774788-Menopause,
pubmed-meshheading:15774788-Middle Aged,
pubmed-meshheading:15774788-Oxygen Consumption,
pubmed-meshheading:15774788-Paclitaxel
|
|
pubmed:year |
2005
|
|
pubmed:articleTitle |
Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications.
|
|
pubmed:affiliation |
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. ataghian@partners.org
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|
