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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5716
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pubmed:dateCreated |
2005-3-18
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pubmed:abstractText |
Type VII collagen defects cause recessive dystrophic epidermolysis bullosa (RDEB), a blistering skin disorder often accompanied by epidermal cancers. To study the role of collagen VII in these cancers, we examined Ras-driven tumorigenesis in RDEB keratinocytes. Cells devoid of collagen VII did not form tumors in mice, whereas those retaining a specific collagen VII fragment (the amino-terminal noncollagenous domain NC1) were tumorigenic. Forced NC1 expression restored tumorigenicity to collagen VII-null epidermis in a non-cell-autonomous fashion. Fibronectin-like sequences within NC1 (FNC1) promoted tumor cell invasion in a laminin 5-dependent manner and were required for tumorigenesis. Tumor-stroma interactions mediated by collagen VII thus promote neoplasia, and retention of NC1 sequences in a subset of RDEB patients may contribute to their increased susceptibility to squamous cell carcinoma.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
18
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pubmed:volume |
307
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1773-6
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:15774758-Adolescent,
pubmed-meshheading:15774758-Adult,
pubmed-meshheading:15774758-Animals,
pubmed-meshheading:15774758-Antibodies,
pubmed-meshheading:15774758-Apoptosis,
pubmed-meshheading:15774758-Carcinoma, Squamous Cell,
pubmed-meshheading:15774758-Cell Adhesion Molecules,
pubmed-meshheading:15774758-Cell Proliferation,
pubmed-meshheading:15774758-Cell Transformation, Neoplastic,
pubmed-meshheading:15774758-Child,
pubmed-meshheading:15774758-Collagen Type VII,
pubmed-meshheading:15774758-Disease Susceptibility,
pubmed-meshheading:15774758-Epidermolysis Bullosa Dystrophica,
pubmed-meshheading:15774758-Female,
pubmed-meshheading:15774758-Genes, ras,
pubmed-meshheading:15774758-Humans,
pubmed-meshheading:15774758-I-kappa B Proteins,
pubmed-meshheading:15774758-Keratinocytes,
pubmed-meshheading:15774758-Male,
pubmed-meshheading:15774758-Mice,
pubmed-meshheading:15774758-Mice, SCID,
pubmed-meshheading:15774758-Middle Aged,
pubmed-meshheading:15774758-Mutation,
pubmed-meshheading:15774758-Neoplasm Invasiveness,
pubmed-meshheading:15774758-Protein Structure, Tertiary,
pubmed-meshheading:15774758-Skin Neoplasms
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pubmed:year |
2005
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pubmed:articleTitle |
Type VII collagen is required for Ras-driven human epidermal tumorigenesis.
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pubmed:affiliation |
VA Palo Alto Healthcare System, Palo Alto, CA 94304, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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