Source:http://linkedlifedata.com/resource/pubmed/id/15774621
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2005-6-21
|
| pubmed:abstractText |
Using a combination of molecular cytogenetic and large-scale expression analysis in human T-cell acute lymphoblastic leukemias (T-ALLs), we identified and characterized a new recurrent chromosomal translocation, targeting the major homeobox gene cluster HOXA and the TCRB locus. Real-time quantitative polymerase chain reaction (RQ-PCR) analysis showed that the expression of the whole HOXA gene cluster was dramatically dysregulated in the HOXA-rearranged cases, and also in MLL and CALM-AF10-related T-ALL cases, strongly suggesting that HOXA genes are oncogenic in these leukemias. Inclusion of HOXA-translocated cases in a general molecular portrait of 92 T-ALLs based on large-scale expression analysis shows that this rearrangement defines a new homogeneous subgroup, which shares common biologic networks with the TLX1- and TLX3-related cases. Because T-ALLs derive from T-cell progenitors, expression profiles of the distinct T-ALL subgroups were analyzed with respect to those of normal human thymic subpopulations. Inappropriate use or perturbation of specific molecular networks involved in thymic differentiation was detected. Moreover, we found a significant association between T-ALL oncogenic subgroups and ectopic expression of a limited set of genes, including several developmental genes, namely HOXA, TLX1, TLX3, NKX3-1, SIX6, and TFAP2C. These data strongly support the view that the abnormal expression of developmental genes, including the prototypical homeobox genes HOXA, is critical in T-ALL oncogenesis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0006-4971
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
106
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
274-86
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:15774621-Adolescent,
pubmed-meshheading:15774621-Adult,
pubmed-meshheading:15774621-Aged,
pubmed-meshheading:15774621-Cell Differentiation,
pubmed-meshheading:15774621-Child,
pubmed-meshheading:15774621-Child, Preschool,
pubmed-meshheading:15774621-Female,
pubmed-meshheading:15774621-Gene Expression Profiling,
pubmed-meshheading:15774621-Gene Expression Regulation, Leukemic,
pubmed-meshheading:15774621-Homeodomain Proteins,
pubmed-meshheading:15774621-Humans,
pubmed-meshheading:15774621-Infant,
pubmed-meshheading:15774621-Leukemia-Lymphoma, Adult T-Cell,
pubmed-meshheading:15774621-Male,
pubmed-meshheading:15774621-Middle Aged,
pubmed-meshheading:15774621-Multigene Family,
pubmed-meshheading:15774621-T-Lymphocytes,
pubmed-meshheading:15774621-Translocation, Genetic
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL).
|
| pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale Lymphocyte et Cancer, and Molecular Hematology Laboratory, Hôpital Saint Louis, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|