Source:http://linkedlifedata.com/resource/pubmed/id/15773956
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2005-3-18
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| pubmed:abstractText |
Elevated pulmonary vascular resistance (PVR) is a well-known risk factor for right ventricular failure after orthotopic cardiac transplantation. The influence of preoperative transpulmonary pressure gradient (TPG) and PVR on post-transplant 30 days mortality was evaluated. To analyze the response of PVR and TPG to cardiac transplantation, we analyzed 718 adult patients undergoing primary cardiac transplantation. Indications for operation were: 35.2% ischemic cardiomyopathy (ICM), 61.2% idiopathic dilated cardiomyopathy (DCM), and 3.3% other diagnosis (e.g. hypertrophic cardiomyopathy). The mean age (51.9) and the mean ischemic time (169.7 min) were comparable between 30 days survivors and nonsurvivors. Student's t-tests and chi-square analysis were used to compare data from 30-day survivors and nonsurvivors. Statistical significance was defined as P < 0.05. Fisher's exact test and multiple logistic regression analysis was performed to evaluate the relationship between hemodynamic parameters and outcome after transplantation. Primary end-point was 30 days mortality and secondary end-point long-term survival of patient groups with different TPG and PVR values. In survivors the mean TPG was 10.3 +/- 5.1 (mean +/- SD) vs. 13 +/- 6.6 in patients who died after transplantation (P = 0.0012). The PVR was 2.6 +/- 1.4 vs. 3.5 +/- 2.2 (P = 0.0012). In multivariate logistic regression, the parameters TPG and PVR exhibit a significant influence between survivors and nonsurvivors after cardiac transplantation within 30 days (TPG: P = 0.0012; PVR: P = 0.0012). The mortality rates in patients with TPG > 11 mmHg and PVR < 2.8 Wood units or TPG < 11 mmHg and PVR > 2.8 Wood units were comparable to those with TPG < 11 mmHg and PVR < 2.8 mmHg. The TPG is an important predictor in nonrejection-related early mortality after orthotopic cardiac transplantation. The determination of TPG in combination with PVR is a more reliable predictor of early post-transplant survival than PVR alone.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
0934-0874
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| pubmed:author |
pubmed-author:AnkersmitJanJ,
pubmed-author:DunklerDanielaD,
pubmed-author:FieglNikolausN,
pubmed-author:GorlitzerMichaelM,
pubmed-author:GrabenwoegerMartinM,
pubmed-author:GrimmMichaelM,
pubmed-author:KiloJulianeJ,
pubmed-author:LanzenbergerMichaelaM,
pubmed-author:MeinhartJohannJ,
pubmed-author:UnalKezibanK,
pubmed-author:WolnerErnstE
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| pubmed:issnType |
Print
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| pubmed:volume |
18
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
390-5
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| pubmed:meshHeading |
pubmed-meshheading:15773956-Adult,
pubmed-meshheading:15773956-Blood Pressure,
pubmed-meshheading:15773956-Cohort Studies,
pubmed-meshheading:15773956-Female,
pubmed-meshheading:15773956-Heart Transplantation,
pubmed-meshheading:15773956-Humans,
pubmed-meshheading:15773956-Male,
pubmed-meshheading:15773956-Middle Aged,
pubmed-meshheading:15773956-Multivariate Analysis,
pubmed-meshheading:15773956-Predictive Value of Tests,
pubmed-meshheading:15773956-Preoperative Care,
pubmed-meshheading:15773956-Prognosis,
pubmed-meshheading:15773956-Proportional Hazards Models,
pubmed-meshheading:15773956-Pulmonary Circulation,
pubmed-meshheading:15773956-Retrospective Studies,
pubmed-meshheading:15773956-Survival Analysis,
pubmed-meshheading:15773956-Vascular Resistance
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| pubmed:year |
2005
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| pubmed:articleTitle |
Is the transpulmonary pressure gradient a predictor for mortality after orthotopic cardiac transplantation?
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| pubmed:affiliation |
Hospital Lainz, Vienna, Austria.
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| pubmed:publicationType |
Journal Article
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