Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 2
pubmed:dateCreated
2005-7-4
pubmed:abstractText
We reported previously that the human RNF2 (RING finger protein 2) protein is an E3 ubiquitin ligase that interacts with the human ubiquitin-conjugating enzyme Hip-2/hE2-25K. In the present study, we show that RNF2 interacts with S6' ATPase, a subunit of the proteasomal 19 S regulatory complex. S6' interacts with RNF2 through its N-terminal RING domain, and RNF2 interacts with S6' through its C-terminal region. Interestingly, the RNF2-S6' interaction increases the ATP hydrolysis activity of the S6' protein. Moreover, S6' ATPase activity is highly increased in the presence of ubiquitinated proteins. The present study suggests that the E3 ubiquitin ligase RNF2 might have a dual function: facilitating the ubiquitination of its target substrates and recruiting the substrates to the proteasome. Furthermore, ATP hydrolysis in the E3/proteasome complex might act as an important signal for the protein degradation pathway.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-10361001, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-10567911, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-10625621, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-10688918, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-10797484, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11007473, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11029046, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11223033, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11278995, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11312667, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11387208, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11395416, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11463857, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11500370, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11513855, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11740563, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11961560, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-11988752, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-12447385, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-12463161, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-12517449, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-1378397, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-14556007, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-8607789, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-8955078, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-9327593, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-9759494, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-9844630, http://linkedlifedata.com/resource/pubmed/commentcorrection/15773819-9857172
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1470-8728
pubmed:author
pubmed:issnType
Electronic
pubmed:day
15
pubmed:volume
389
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
457-63
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
E3 ubiquitin ligase RNF2 interacts with the S6' proteasomal ATPase subunit and increases the ATP hydrolysis activity of S6'.
pubmed:affiliation
Graduate School of Biotechnology, Korea University, 1,5-ka Anam-dong, Seoul 136-701, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't