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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2005-6-28
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pubmed:abstractText |
Transforming growth factor beta (TGFbeta1) is considered the key mediator in the process of liver fibrosis. The purpose of this investigation was to evaluate the activity of ribozymes against TGFbeta1 in a cell-free system and activated hepatic stellate cells (HSCs), and antifibrotic effect in activated HSCs in vitro and in rats.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1099-498X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2005 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
965-76
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:15772939-Animals,
pubmed-meshheading:15772939-Base Sequence,
pubmed-meshheading:15772939-Cell Proliferation,
pubmed-meshheading:15772939-Cell-Free System,
pubmed-meshheading:15772939-Cells, Cultured,
pubmed-meshheading:15772939-Collagen Type I,
pubmed-meshheading:15772939-Genetic Vectors,
pubmed-meshheading:15772939-Interferon-gamma,
pubmed-meshheading:15772939-Liver,
pubmed-meshheading:15772939-Liver Cirrhosis,
pubmed-meshheading:15772939-Models, Biological,
pubmed-meshheading:15772939-Molecular Sequence Data,
pubmed-meshheading:15772939-RNA, Catalytic,
pubmed-meshheading:15772939-RNA, Small Nuclear,
pubmed-meshheading:15772939-Rats,
pubmed-meshheading:15772939-Transfection,
pubmed-meshheading:15772939-Transforming Growth Factor beta
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pubmed:year |
2005
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pubmed:articleTitle |
Ribozymes against TGFbeta1 reverse character of activated hepatic stellate cells in vitro and inhibit liver fibrosis in rats.
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pubmed:affiliation |
Institute of Liver Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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