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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1992-6-9
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pubmed:databankReference |
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pubmed:abstractText |
TFIIIA mRNA expression is developmentally regulated during Xenopus oogenesis. We have identified a positive-acting cis-element in the TFIIIA gene located between -671 and -629 with respect to the mRNA initiation site, termed element 3. Element 3 contributes to the efficient transcription of the TFIIIA gene in stage III oocytes, but is inactive in the normal context of the TFIIIA gene in stage VI oocytes. A trans-acting factor, termed B3, in immature ovary extracts binds to a region within element 3 containing four repeats of the consensus nucleotide sequence 5' (T/A)GGTTACT. We discuss how the developmental regulation of B3-element 3 function could be achieved in the context of the TFIIIA gene during oogenesis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-1606
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
306-16
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1577195-Animals,
pubmed-meshheading:1577195-Base Sequence,
pubmed-meshheading:1577195-Binding, Competitive,
pubmed-meshheading:1577195-Chromosome Mapping,
pubmed-meshheading:1577195-DNA-Binding Proteins,
pubmed-meshheading:1577195-Female,
pubmed-meshheading:1577195-Molecular Sequence Data,
pubmed-meshheading:1577195-Oocytes,
pubmed-meshheading:1577195-Oogenesis,
pubmed-meshheading:1577195-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:1577195-Trans-Activators,
pubmed-meshheading:1577195-Transcription Factor TFIIIA,
pubmed-meshheading:1577195-Transcription Factors,
pubmed-meshheading:1577195-Xenopus
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pubmed:year |
1992
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pubmed:articleTitle |
Characterization of a Xenopus oocyte factor that binds to a developmentally regulated cis-element in the TFIIIA gene.
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pubmed:affiliation |
Department of Molecular Physiology and Biophysics, School of Medicine, Vanderbilt University, Nashville, Tennessee 37232-0615.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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