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pubmed-article:15769913pubmed:abstractTextTumour necrosis alpha (TNF alpha) blocking agents lead to pronounced clinical effects and reduced synovial infiltrate in rheumatoid arthritis. Laboratory and clinical studies suggest that TNF alpha independent pathways play a role in the disease.lld:pubmed
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pubmed-article:15769913pubmed:articleTitleClinical efficacy of infliximab plus methotrexate in DMARD naive and DMARD refractory rheumatoid arthritis is associated with decreased synovial expression of TNF alpha and IL18 but not CXCL12.lld:pubmed
pubmed-article:15769913pubmed:affiliationLeiden University Medical Centre, Department of Rheumatology, PO Box 9600, 2300 RC Leiden, Netherlands. M.van_Oosterhout@LUMC.nllld:pubmed
pubmed-article:15769913pubmed:publicationTypeJournal Articlelld:pubmed
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