Linked Life Data

15769861

Source:http://linkedlifedata.com/resource/pubmed/id/15769861

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
2005-3-30
pubmed:abstractText
Multiple unstable spiral waves rotating around phase singularities (PSs) in the heart, i.e., ventricular fibrillation (VF), is the leading cause of death in the industrialized world. Spiral waves are ubiquitous in nature and have been extensively studied by physiologists, mathematicians, chemists, and biologists, with particular emphasis on their movement and stability. Spiral waves are not easy to terminate because of the difficulty of "breaking" the continuous spatial progression of phase around the PSs. The only means to stop VF (i.e., cardiac defibrillation) is to deliver a strong electric shock to the heart. Here, we use the similarities between spiral wave dynamics and limit cycle oscillators to characterize the spatio-temporal dynamics of VF and defibrillation via phase-resetting curves. During VF, only PSs, including their formation and termination, were associated with large phase changes. At low shock strengths, phase-resetting curves exhibited characteristics of weak (type 1) resetting. As shock strength increased, the number of postshock PSs decreased to zero coincident with a transition to strong (type 0) resetting. Our results indicate that shock-induced spiral wave termination in the heart is caused by altering the phase around the PSs, such that, depending on the preshock phase, sites are either excited by membrane depolarization (phase advanced) or exhibit slowed membrane repolarization (phase delay). Strong shocks that defibrillate break the continuity of phase around PSs by forcing the state of all sites to the fast portion of state space, thus quickly leading to a "homogeneity of state," subsequent global repolarization and spiral wave termination.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-11017437, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-11551885, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-12719224, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-12971610, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-14732200, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-15089996, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-15363669, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-1572041, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-1731248, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-493975, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-7313693, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-7973648, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-8431989, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-8577731, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-8692824, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-887919, http://linkedlifedata.com/resource/pubmed/commentcorrection/15769861-9510249
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
102
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4672-7
pubmed:dateRevised
2010-9-20
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Termination of spiral waves during cardiac fibrillation via shock-induced phase resetting.
pubmed:affiliation
Department of Biomedical Engineering, University of Alabama at Birmingham, AL 35294, USA. rag@crml.uab.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural