Linked Life Data

15769629

Source:http://linkedlifedata.com/resource/pubmed/id/15769629

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-3-16
pubmed:abstractText
The deposition of calcium-containing crystals in articular tissues is probably an underrecognized event. Clinical observations indicate that exaggerated and uniquely distributed cartilage degeneration is associated with these deposits. Perhaps the most compelling argument favoring a role for crystals in causing osteoarthritis stems from their in vitro effects on articular tissues. In this review, we will highlight some of the recent findings that further reinforce the thesis that basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPPD) crystals can cause the degeneration of articular tissues in 2 separate pathways. In the "Direct" pathway, crystals directly induce fibro-blast-like synoviocytes to proliferate and produce metalloproteinases and prostaglandins. The other "Paracrine Pathway" involves the interaction between crystals and macrophages/monocytes which leads to synthesis and release of cytokines which can reinforce the action of crystals on synoviocytes and/or induce chondrocytes to secrete enzymes and which eventually cause the degeneration of articular tissues.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1093-4715
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1336-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Role of calcium-containing crystals in osteoarthritis.
pubmed:affiliation
Miami VA Medical Center and Dept. of Biomedical Engineering, University of Miami, 1201 N.W. 16th St. Miami, FL 33125, USA. hcheung@med.miami.edu <hcheung@med.miami.edu>
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, N.I.H., Extramural