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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-6-5
|
| pubmed:abstractText |
The v-myb oncogene of the acute avian leukemia virus E26 encodes a transcription factor that directly regulates the promyelocyte-specific mim-1 gene (Ness, S.A., Marknell, A. and Graf, T. Cell, 59, 1115-1125). We have investigated the relationship between the c-myb proto-oncogene and the transcription of the mim-1 gene both in vitro and in vivo. We demonstrate that the c-myb protein can transactivate the transcription of mim-1 in a transient transfection assay. In the chick embryo, we confirm that mim-1 is specifically expressed during granulopoiesis and we show that the expression of c-myb and mim-1 are perfectly correlated in the granulocytic spleen and pancreas. However we suggest that mim-1 is efficiently transcribed in the absence of c-myb in the yolk sac and in the promyelocytes at the onset of the colonization of the bursa of Fabricius. On the other hand c-myb transcripts detected in the early hemopoietic progenitor cells, in lymphoid cells and in proliferative epithelia are never associated with mim-1 transcription. We conclude that the granulocyte-specific mim-1 gene is regulated by c-myb-dependent and c-myb-independent mechanisms depending upon the environment in which granulocytic precursor cells differentiate.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Growth Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Oncogene Proteins v-myb,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myb,
http://linkedlifedata.com/resource/pubmed/chemical/Retroviridae Proteins, Oncogenic
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0950-1991
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
114
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
125-33
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:1576954-Animals,
pubmed-meshheading:1576954-Cell Differentiation,
pubmed-meshheading:1576954-Chick Embryo,
pubmed-meshheading:1576954-Genes,
pubmed-meshheading:1576954-Granulocytes,
pubmed-meshheading:1576954-Growth Substances,
pubmed-meshheading:1576954-Hematopoiesis,
pubmed-meshheading:1576954-Muscles,
pubmed-meshheading:1576954-Oncogene Proteins v-myb,
pubmed-meshheading:1576954-Pancreas,
pubmed-meshheading:1576954-Proto-Oncogene Proteins,
pubmed-meshheading:1576954-Proto-Oncogene Proteins c-myb,
pubmed-meshheading:1576954-Retroviridae Proteins, Oncogenic,
pubmed-meshheading:1576954-Spleen,
pubmed-meshheading:1576954-Thymus Gland,
pubmed-meshheading:1576954-Transcription, Genetic,
pubmed-meshheading:1576954-Transcriptional Activation,
pubmed-meshheading:1576954-Yolk Sac
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Expression patterns of c-myb and of v-myb induced myeloid-1 (mim-1) gene during the development of the chick embryo.
|
| pubmed:affiliation |
INSERM U186/CNRS URA1160, Institut Pasteur, Lille, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|