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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1992-6-5
|
| pubmed:abstractText |
There are few reports on the genetic, immunological and nutritional characteristics of insulin-using youth-onset diabetes mellitus, insulin-dependent diabetes mellitus (IDDM) and malnutrition-related diabetes mellitus (MRDM) in Korea. Among 1266 hospitalized Korean diabetics, 29 (2.3%) were IDDM and 84 (6.6%) were MRDM. A diabetes history of first-relatives (28.6%) was more frequently found in the MRDM group than in the IDDM (14.8) and non-insulin-dependent diabetes mellitus (NIDDM) (19.0%) groups. HLA-DR4 was more common among IDDM (54.2%) and MRDM (52.4%) patients than controls (26.3%), and HLA-DR3 was more common among only IDDM patients (29.2%) than controls (10.9%). Conventional islet-cell antibodies were detected in 8 of 15 IDDM patients tested (53.3%) and in 11 of 22 MRDM patients (50.0%). MRDM patients had higher serum basal (1.02 +/- 0.51 ng/ml) and peak (1.44 +/- 0.76 ng/ml) C-peptide concentrations than IDDM patients, but lower concentrations than NIDDM patients. Before the onset of diabetes, the calorie intake of 21 MRDM patients assessed was 63.1% of the daily requirement and the intake of carbohydrate, protein and fat was 71.7%, 55.9% and 39.8%, respectively. In summary, our data suggest that IDDM in Korea is associated with HLA-DR3 or HLA-DR4, indicating a risk for IDDM in Western societies; furthermore, MRDM has a history of undernutrition at the preonset period and is also associated with HLA-DR4. It might be also concluded that MRDM in Korea is another expression of IDDM caused by the shortage of some nutrients for the structural and/or functional maintenance of pancreatic beta-cells.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Autoantibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/C-Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-DR Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin A, Glycosylated,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamins,
http://linkedlifedata.com/resource/pubmed/chemical/islet cell antibody
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0168-8227
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
16
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
63-70
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1576933-Adolescent,
pubmed-meshheading:1576933-Autoantibodies,
pubmed-meshheading:1576933-Blood Glucose,
pubmed-meshheading:1576933-Blood Proteins,
pubmed-meshheading:1576933-C-Peptide,
pubmed-meshheading:1576933-Cholesterol, HDL,
pubmed-meshheading:1576933-Diabetes Mellitus,
pubmed-meshheading:1576933-Diabetes Mellitus, Type 1,
pubmed-meshheading:1576933-Diet,
pubmed-meshheading:1576933-Female,
pubmed-meshheading:1576933-Glucose Tolerance Test,
pubmed-meshheading:1576933-HLA-DR Antigens,
pubmed-meshheading:1576933-Hemoglobin A, Glycosylated,
pubmed-meshheading:1576933-Humans,
pubmed-meshheading:1576933-Islets of Langerhans,
pubmed-meshheading:1576933-Korea,
pubmed-meshheading:1576933-Male,
pubmed-meshheading:1576933-Nutrition Disorders,
pubmed-meshheading:1576933-Triglycerides,
pubmed-meshheading:1576933-Vitamins
|
| pubmed:year |
1992
|
| pubmed:articleTitle |
Immunogenetic and nutritional profile in insulin-using youth-onset diabetics in Korea.
|
| pubmed:affiliation |
Department of Internal Medicine, Yonsei University, Seoul, Korea.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|