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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2005-3-15
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pubmed:abstractText |
Angiogenesis inhibitors, such as TNP-470 and the nontoxic HPMA copolymer-TNP-470 (caplostatin), are emerging as a class of anticancer drugs. We report that TNP-470 and caplostatin inhibit vascular hyperpermeability of tumor blood vessels as well as that induced in mouse skin by different mediators. Treatment with TNP-470 or angiostatin for 3 days was sufficient to reduce permeability of tumor blood vessels, delayed-type hypersensitivity, and pulmonary edema induced by IL-2. TNP-470 also inhibited VPF/VEGF-induced phosphorylation of VEGFR-2, calcium influx, and RhoA activation in endothelial cells. These results identify an activity of TNP-470, that of inhibiting vessel hyperpermeability. This activity likely contributes to TNP-470's antiangiogenic effect and suggests that caplostatin can be used in the treatment of cancer and inflammation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiogenesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Angiostatins,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanes,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/O-(chloroacetylcarbamoyl)fumagillol,
http://linkedlifedata.com/resource/pubmed/chemical/Sesquiterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor A,
http://linkedlifedata.com/resource/pubmed/chemical/Vascular Endothelial Growth Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/rhoA GTP-Binding Protein
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1535-6108
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pubmed:author |
pubmed-author:DvorakAnn MAM,
pubmed-author:DvorakHarold FHF,
pubmed-author:FengDianD,
pubmed-author:FolkmanJudahJ,
pubmed-author:MamlukRoniR,
pubmed-author:MukhopadhyayDebabrataD,
pubmed-author:NagyJanice AJA,
pubmed-author:PuderMarkM,
pubmed-author:Satchi-FainaroRonitR,
pubmed-author:ShortSarah MSM,
pubmed-author:WangLingL
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
251-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:15766663-Angiogenesis Inhibitors,
pubmed-meshheading:15766663-Angiostatins,
pubmed-meshheading:15766663-Animals,
pubmed-meshheading:15766663-Calcium,
pubmed-meshheading:15766663-Capillaries,
pubmed-meshheading:15766663-Capillary Permeability,
pubmed-meshheading:15766663-Cell Movement,
pubmed-meshheading:15766663-Cyclohexanes,
pubmed-meshheading:15766663-Endothelial Cells,
pubmed-meshheading:15766663-Female,
pubmed-meshheading:15766663-Hypersensitivity, Delayed,
pubmed-meshheading:15766663-Interleukin-2,
pubmed-meshheading:15766663-Male,
pubmed-meshheading:15766663-Mice,
pubmed-meshheading:15766663-Mice, Inbred C57BL,
pubmed-meshheading:15766663-Mice, SCID,
pubmed-meshheading:15766663-Mitogen-Activated Protein Kinases,
pubmed-meshheading:15766663-Neoplasms,
pubmed-meshheading:15766663-Pulmonary Edema,
pubmed-meshheading:15766663-Sesquiterpenes,
pubmed-meshheading:15766663-Skin,
pubmed-meshheading:15766663-Vascular Endothelial Growth Factor A,
pubmed-meshheading:15766663-Vascular Endothelial Growth Factor Receptor-2,
pubmed-meshheading:15766663-rhoA GTP-Binding Protein
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pubmed:year |
2005
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pubmed:articleTitle |
Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin.
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pubmed:affiliation |
Children's Hospital Boston and Harvard Medical School, Vascular Biology Program, Department of Surgery, 1 Blackfan Circle, Karp Family Research Laboratories, Floor 12, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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