| pubmed-article:1576536 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1576536 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:1576536 | lifeskim:mentions | umls-concept:C0376604 | lld:lifeskim |
| pubmed-article:1576536 | lifeskim:mentions | umls-concept:C0034830 | lld:lifeskim |
| pubmed-article:1576536 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:1576536 | lifeskim:mentions | umls-concept:C0022510 | lld:lifeskim |
| pubmed-article:1576536 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:1576536 | pubmed:dateCreated | 1992-6-8 | lld:pubmed |
| pubmed-article:1576536 | pubmed:abstractText | Whole-cell recording techniques were used to examine acetylcholine-induced nicotinic currents in isolated bovine chromaffin cells. The effects on these currents of kappa-bungarotoxin, a snake venom kappa-neurotoxin, were tested. Exposure of cells to kappa-bungarotoxin (600 nM for 40 min) produced a prolonged blockade of nicotinic currents. The mechanism of this blockade was examined in several ways. Firstly, the pre-exposure of cells to trimetaphan, a competitive nicotinic antagonist, protected against the action of subsequent additions of kappa-bungarotoxin. Secondly, voltage-clamp measurements indicated that the degree of blockade produced by kappa-bungarotoxin was independent of cell membrane potential. Unlike (+)-tubocurarine, kappa-bungarotoxin had no direct agonist effects on nicotinic receptors. It is concluded from the present functional studies and from previously reported binding studies that kappa-bungarotoxin blocks nicotinic responses in bovine chromaffin cells by binding to regions overlying acetylcholine sites on nicotinic receptors. | lld:pubmed |
| pubmed-article:1576536 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576536 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576536 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1576536 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576536 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:1576536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576536 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1576536 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1576536 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:1576536 | pubmed:issn | 0006-8993 | lld:pubmed |
| pubmed-article:1576536 | pubmed:author | pubmed-author:ChiappinelliV... | lld:pubmed |
| pubmed-article:1576536 | pubmed:author | pubmed-author:LambertJ JJJ | lld:pubmed |
| pubmed-article:1576536 | pubmed:author | pubmed-author:NooneyJ MJM | lld:pubmed |
| pubmed-article:1576536 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1576536 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:1576536 | pubmed:volume | 573 | lld:pubmed |
| pubmed-article:1576536 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1576536 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1576536 | pubmed:pagination | 77-82 | lld:pubmed |
| pubmed-article:1576536 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:meshHeading | pubmed-meshheading:1576536-... | lld:pubmed |
| pubmed-article:1576536 | pubmed:year | 1992 | lld:pubmed |
| pubmed-article:1576536 | pubmed:articleTitle | The interaction of kappa-bungarotoxin with the nicotinic receptor of bovine chromaffin cells. | lld:pubmed |
| pubmed-article:1576536 | pubmed:affiliation | Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital, University of Dundee, U.K. | lld:pubmed |
| pubmed-article:1576536 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1576536 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1576536 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1576536 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1576536 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:1576536 | lld:pubmed |
