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pubmed-article:15764084pubmed:abstractTextExcessive activation of poly(ADP-ribose) polymerase (PARP), a nuclear enzyme that is activated by DNA damage, leads to neuronal cell death through depletion of ATP. The purpose of this study was to determine whether inhibition of PARP has some neuroprotective effects on the N-methyl-D-aspartate (NMDA)-induced functional and morphological injury to the rabbit retina.lld:pubmed
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pubmed-article:15764084pubmed:articleTitleEffects of poly(ADP-ribose) polymerase inhibitor on NMDA-induced retinal injury.lld:pubmed
pubmed-article:15764084pubmed:affiliationDepartment of Ophthalmology, Osaka Medical College, Osaka, Japan. hidehirooku@aol.comlld:pubmed
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